| ZHAO Ying-chao,DAI Xiao-fang,WU Gang,et al.Clinical comparative investigation using intensity-modulated radiotherapy combined with concurrent chemotherapy for the local advanced nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2009,29(4):414-417 |
| Clinical comparative investigation using intensity-modulated radiotherapy combined with concurrent chemotherapy for the local advanced nasopharyngeal carcinoma |
| Received:March 18, 2009 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasms Intensity modulated radiation therapy Chemotherapy Tolerance |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHAO Ying-chao | Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China | | | DAI Xiao-fang | Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China | daixiaofang70@yahoo.com.cn | | WU Gang | Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China | | | ZHAO Yan-xia | Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China | | | LUO Ming | Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China | |
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| Abstract:: |
| Objective To research the early effects and side-effects of the local advanced nasopharyngeal carcinoma patients using intensity-modulated radiotherapy (IMRT) combined with concurrent chemotherapy. Methods From January 2005 to January 2007, 60 patients with nasopharyngeal carcinoma of stage Ⅲ-Ⅳb were received IMRT combined with concurrent chemotherapy in our center. Sixty patients were divided into paclitaxel concurrent group (32 patients) and cisplatin concurrent group (28 patients). The prescribing doses of the primary tumor were 68-72 Gy for each group. The patients of paclitaxel concurrent group received 5-7 times paclitaxel liposome chemotherapy of 30 mg·m-2·week-1. The patients of cisplatin concurrent group received 5-7 times cisplatin chemotherapy of 30 mg·m-2·week-1. Results As to the side-effects, the patients of the cisplatin concurrent group got earlier radiodermatitis and radiation-induced mucositis but also got significantly higher rate of radiodermatitis,radiation-induced mucositis,radiation-induced leucopenia and gastrointestinal toxicity, as well as the loss of weight. No significant difference was found on liver and renal functions between two groups. Four patients (12.5%) of the paclitaxel concurrent group were broken-off, which was much better than the cisplatin concurrent group. There was no significant difference on the specific length of break-off time, the 2-year overall survival rate and the 2-year disease-free survival rate between two groups. Conclusions IMRT combined with concurrent chemotherapy of paclitaxel liposome for local advanced nasopharyngeal carcinoma results in less side-effects and better tolerance than IMRT combined with concurrent cisplatin chemotherapy. |
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