| ZHENG Hui,ZHEN Rong,TU Xu-min,et al.Changes of T-lymphocyte function subsets and IL-4 and IFN-γ after irradiation injury[J].Chinese Journal of Radiological Medicine and Protection,2009,29(4):386-388 |
| Changes of T-lymphocyte function subsets and IL-4 and IFN-γ after irradiation injury |
| Received:September 28, 2008 |
| DOI： |
| KeyWords:Radiation Immune Harm T-lymphocyte subsets IL-4 IFN-γ |
| FundProject: |
| Author Name | Affiliation | | ZHENG Hui | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | ZHEN Rong | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | TU Xu-min | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | ZHANG Zhi-xing | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China |
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| Abstract:: |
| Objective To observe the effects of T-lymphocyte function subsets,IL-4 and IFN-γ cell factor in different dose and stage after irradiation. Methods The C57BL/6j mice were divided into shammed irradiation group and model groups. The radiation hurt model was induced by 60Co gamma rays (0.7, 1.4, 2.8 and 5.6 Gy). The changes of T- lymphocyte subsets CD3,CD4,CD8, IL-4 and IFN-γ in spleen cells were analyzed by flow cytometry in acute injury stage and recovery stage after irradiation. Results The lymphocyte subsets CD3+, CD4+ and CD8+ decreased after irradiation,which were related to the irradiation dose. At 1 day after irradiation, the decreasing level of IFN-γ was higher than that of IL-4. When irradiation dose was over 2.8 Gy, IL-4 / IFN-γ showed a markedly increased compared with control group. At 25 days after irradiation, CD3+,CD4+,CD8+,CD4+/CD8+,IL-4 and IFN-γ recovered obviously, but they did not recover to the normal level of shammed irradiation group. Conclusions The depression of mouse immune function induced by γ-irradiation might be caused by changes of CD3,CD4,CD8 and CD4/CD8 ratio, especially the imbalance of IL-4 and IFN-γ. |
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