| ZHANG Hai,WANG Bing-sheng,LIU Xiu-fang,LI Feng-yu,LUO Shu-peng,LI Hong-wei,SHI Jun.Effect of Yiqi Huoxue Recipe on the expression of TGF-β1, TNF-α in rats[J].Chinese Journal of Radiological Medicine and Protection,2009,29(4):383-385 |
| Effect of Yiqi Huoxue Recipe on the expression of TGF-β1, TNF-α in rats |
| Received:April 30, 2009 |
| DOI： |
| KeyWords:Radiation-induced lung injury TGF-β1 TNF-α Yiqi Huoxue |
| FundProject:全军医学科学技术研究"十一五"计划课题(06MB084) |
| Author Name | Affiliation | E-mail | | ZHANG Hai | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | | | WANG Bing-sheng | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | wbsh_2000@sina.com | | LIU Xiu-fang | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | | | LI Feng-yu | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | | | LUO Shu-peng | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | | | LI Hong-wei | 解放军第二五一医院肿瘤诊疗中心, 病理科 | | | SHI Jun | Department of Tumor, 251th Hospital of PLA, Zhangjiakou 075000, China | |
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| Abstract:: |
| Objective To observe the effect of Yiqi Huoxue Recipe on the expression of TGF-β1 and TNF-α on serum and lung of rats with radiation-induced lung injury in different radiation time, and discuss the preventative and curative effect and mechanisms of Yiqi Huoxue Recipe. Methods 66 Wistar rats were randomly allocated into irradiation with Yiqi Huoxue Recipe-treated group (A group) irradiation group (B group), and normal control group (C group). The first two groups were irradiated at right hemithorax with a dose of 30 Gy/6 fractions (in 6 weeks). The levels of TGF-β1 and TNF-α on rat serum and lung were measured by ELISA and immunohistochemistry at the end of the 4th, 6th, 8th, 12th, and 26th week after the first irradiation. Results TGF-β1 and TNF-α level on rats serum and lung in irradiation group showed an increase from the 4th week after the first irradiation, peaking at the 12th week, and descending at the 26th week. In A group, the levels of TGF-β1 and TNF-α were significantly lower from the 4th week than those of B group. Conclusions Yiqi Huoxue Recipe could inhibit the excretion of TGF-β1 and TNF-α and might play an important role in the prevention and curation of radiation-induced lung injury, which might be related to inhibiting the expression of TGF-β1 and TNF-α. |
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