| HE Guan-qiang,ZHENG Miao,SUN Han-ying,ZHANG Na,HUANG Li-fang,WANG Fang,LIU Wen-li.Effects of simvastatin on the recovery of hematopoiesis in acute irradiation injured mice[J].Chinese Journal of Radiological Medicine and Protection,2009,29(4):372-374 |
| Effects of simvastatin on the recovery of hematopoiesis in acute irradiation injured mice |
| Received:December 27, 2008 |
| DOI： |
| KeyWords:Simvastatin Osteoblast Irradiation injury Bone marrow Hematopoietic recovery |
| FundProject:国家自然科学基金(30570773);高等学校博士学科点专项科研基金(200804871044) |
| Author Name | Affiliation | E-mail | | HE Guan-qiang | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | ZHENG Miao | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | SUN Han-ying | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | ZHANG Na | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | HUANG Li-fang | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | WANG Fang | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | LIU Wen-li | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | liuwenli1945@sina.com.cn |
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| Abstract:: |
| Objective To investigate the effect of simvastatin on hematopoiesis in acute irradiation injured mice. Method\ Sixty-six Kunming mice were randomly divided into 3 groups as normal group, control group and simvastatin group. Control group and simvastatin group were administrated 0.9% saline and simvastatin(16 mg/kg,1 time each day),respectively after 6.0 Gy 60Co γ-rays. The effects were observed at 3rd, 7th, 10th and 14th day after irradiation by evaluating blood cells, bone marrow nucleated cells, the percentage of CD34+ cells and hematopoietic tissue area. The colony forming units of spleen (CFU-S) at 10th day and bone trabecula at 28 day were calculated. Result The peripheral leukocytes, platelets, the bone marrow mononuclear cells (BMNC) counts, and the percentage of CD34+ cells in the bone marrow at each tested time were increased significantly after simvastatin treatment (P<0.05 or P<0.01). The number of bone trabecula at 28th day and CFU-S counts at 10th day in simvastain group were also increased significantly. ConclusionsSimvastatin could accelerate the early phase of hematopoietic recovery in irradiation injured mice by increasing the number of bone trabecula, osteoblasts and CD34+ cells in bone marrow. |
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