| MAO Wei-dong,TIAN Ye.Alteration of S-100B in serum following whole-brain irradiation in rats[J].Chinese Journal of Radiological Medicine and Protection,2009,29(3):271-273 |
| Alteration of S-100B in serum following whole-brain irradiation in rats |
| Received:June 12, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.03.006 |
| KeyWords:Brain irradiation injury Serum S-100B Enzyme-linked immunosorbent assay(ELISA) |
| FundProject:江苏省卫生厅重大科研课题资助项目(K200406);苏州大学医学发展基金资助项目(EE123504) |
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| Abstract:: |
| Objective To investigate the change of S-100B in serum in rats at various times after exposure to different whole-brain irradiation doses and to explore the characteristics of the S-100B change in early radiation-induced brain injuries.Methods A model of brain radiation-induced injuries was established in the rat after whole-brain irradiation with a single dose of 2, 10, or 30 Gy of 4MeV electron. The concentration of S-100B in serum was detected by means of enzyme-linked immunosorbent assay (ELISA) at different time points (1,6,12,24,3 days,1 week,1 month) after exposure.Results In terms of measuring time points, the serum concentration in all groups reached the first peak 6 hours after irradiation, declined after 12 hours, rose again after 24 hours, and started to decline again until the last time point (1 month), with the exception of the 2 Gy group, which reached the second peak at 3 days after irradiation.Conclusions The S-100B serum concentration was changed in the rats after whole-brain irradiation and these changes are positively related to the irradiation amount. It seems that the higher the dose, the higher the serum concentration and the differences between the dose groups are significant (via multiple regression models). The S-100B may be a valuable serum marker for the brain irradiation injury. |
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