| SHANG Xi-mei,CHEN Ying-min,BI Ming-wei,et al.Cytogenetic investigertion on underground workers in gold mine[J].Chinese Journal of Radiological Medicine and Protection,2009,29(2):201-203 |
| Cytogenetic investigertion on underground workers in gold mine |
| Received:January 07, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.02.028 |
| KeyWords:Gold mine Chromosome aberrations Cytokinesis_block micronucleus Occupational hazards |
| FundProject:科技部科研院所社会公益研究专项(2005DIB1J087) |
| Author Name | Affiliation | E-mail | | SHANG Xi-mei | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | CHEN Ying-min | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | Sdfanghu@sohu.com | | BI Ming-wei | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | SONG Gang | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | MA Ya | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | LI Zhen | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | QIAO Jian-wei | Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | |
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| Abstract:: |
| Objective To investigate the chromosome damage in peripheral lymphocytes of underground gold miners.Methods Conventional method and cytokinesis_block micronucleus assay were used to analyze frequency of chromosome aberrations and micronucleus in peripheral lymphocytes in 58 gold miners, respectively.Results Frequencies of chromosome-type aberrations, chromatid-type aberrations and total aberrations were higher in the miners than those in the control group (0.72%, 0.41%,1.16% vs 0.14%, 0.18%,0.33,χ2=44.322,9.501,50.476,P<0.01). Both micronucleated cell rate and micronucleus rate were higher in the miners group than those in the control group (10.8‰ and 11.6‰ vs 8.7‰ and 9.0‰,χ2=8.672,12.546,P<0.01).Frequencies of chromosomal aberrations and micronucleus proportionally increased with underground working years. Compared with those miners who had worked underground 6 years or shorter, both frequencies were statistically higher among the miners who had worked underground for more than 21 years (P<0.05). No difference was found among other groups of working years (P>0.05). Compared with the control group, both frequencies increased in the miner group, and the differences were statistically significant (χ2=2.395, P<0.05 for chromosomal aberrations and χ2=2.319,P<0.05, respectively). The common types of chromosome aberrations were acentric fragments, while chromatid break and dicenrics were subordinate.Conclusions Chromosomal damages were observed in the gold workers who exposed high radon in the underground mining. |
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