| QI Xue-song,HAO Zuo-hong,LU Hui-min,ZHANG Wei,WANG Ping,SU Xu.Correlation between gene polymorphisms of IL-2, IL-6 and TNF-α in workers exposed to rare earth dust and their lung ventilation function[J].Chinese Journal of Radiological Medicine and Protection,2009,29(2):199-200 |
| Correlation between gene polymorphisms of IL-2, IL-6 and TNF-α in workers exposed to rare earth dust and their lung ventilation function |
| Received:January 09, 2009 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.02.027 |
| KeyWords:IL-2 IL-6 TNF-α Gene polymorphism Lung ventilation dysfunction |
| FundProject:科技部科研院所社会公益研究专项(2005DIB1J087) |
| Author Name | Affiliation | E-mail | | QI Xue-song | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | HAO Zuo-hong | 包钢劳动卫生职业病防治研究所 | | | LU Hui-min | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | LuHui-min@163.com | | 王春燕 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | ZHANG Wei | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | WANG Ping | 包钢劳动卫生职业病防治研究所 | | | 郝述霞 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | SU Xu | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | |
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| Abstract:: |
| Objective To study the relationship between lung ventilation function of workers exposed to rare earth dust and their IL-2, IL-6 and TNF-α gene polymorphism. Methods TNF-α gene polymorphism were identified by RFLP-PCR, IL-2 and IL-6 gene polymorphisms were identified by PCR-CTPP analysis. Lung ventilation function was deteced by instrument of ventilation function. Results Compared with controls, there was no statistic significance in frequencies distribution of TNF-α gene polymorphism (χ2=4.03,P>0.05), IL-2 gene polymorphism (χ2=2.21,P>0.05) and IL-6 gene polymorphism (χ2=1.05,P>0.05). Compared with IL-2 gene wild type, IL-2 homozygote type increased the risk of lung ventilation dysfunction by 4.29 folds (95% CI 1.09~16.9). Conclusion Compared with controls, incidence of ventilation function of workers exposed to rare earth dust is in ascending trend. IL-2 (G/G) gene type induces more serious inflammation reaction than the others. |
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