| GUO Zhi-ying,TIAN Mei,LIU Jian-xiang,RUAN Jian-lei,PIAO Chun-nan,SU Xu.Expression of JNK/SAPK in lung and bronchus of radon-exposed mice[J].Chinese Journal of Radiological Medicine and Protection,2009,29(2):192-194 |
| Expression of JNK/SAPK in lung and bronchus of radon-exposed mice |
| Received:December 01, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.02.025 |
| KeyWords:Radon and its progeny Mice Exposure JNK/SAPK(c-Jun NH2-terminal kinase/stress activated protein kinase) |
| FundProject:科技部科研院所社会公益研究专项(2005DIB1J087) |
| Author Name | Affiliation | E-mail | | GUO Zhi-ying | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | TIAN Mei | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | LIU Jian-xiang | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | RUAN Jian-lei | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | PIAO Chun-nan | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | SU Xu | National Institute for Radiological Protection, China CDC, Beijing 100088, China | suxu@nirp.cn |
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| Abstract:: |
| Objective To study the expression of JNK/SAPK(c-Jun NH2-terminal kinase/stress activated protein kinase) in lung and bronchus of radon-exposed mice. Methods Male BALB/c mice were exposed to radon and its progeny with the cumulative dose of 0.02, 30 or 60 working level month (WLM), respectively. The expression levels of JNK/SAPK in lung and bronchus were determined with Real-Time PCR, Western blot and immunohistochemistry methods. Results The JNK mRNA levels in lung tissues of mice exposed to radon of 30 and 60 WLM were higher than those of the control by 3.56 and 2.96 times, respectively. The relative expression levels of JNK and phospho-JNK proteins were higher than those of the control by using Western blot and immunohistochemistry methods. Conclusion Expose to the radon and its progeny might activate the JNK/SAPK intracellular signaling pathway. |
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