| LUO Bo,ZHUANG Liang,XIA Shu,ZHAO Zhen,RONG Lei.Effect of irradiation on EGFR nuclear translocation in cervical carcinoma cell lines[J].Chinese Journal of Radiological Medicine and Protection,2009,29(2):133-135 |
| Effect of irradiation on EGFR nuclear translocation in cervical carcinoma cell lines |
| Received:April 15, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.02.003 |
| KeyWords:EGFR Cervical carcinoma Radiosensitivity |
| FundProject:国家自然科学基金(30672426) |
| Author Name | Affiliation | | 于世英 | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | LUO Bo | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | ZHUANG Liang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | XIA Shu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | ZHAO Zhen | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | RONG Lei | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract:: |
| Objective To observe the EGFR nuclear translocation in cervical carcinoma cell lines after irradiation and its possible role in radiation tolerance.Methods Western blotting was used to detect the nuclear EGFR and cytoplastic EGFR after irradiation. The effect of Cetuximab on expression of nuclear EGFR and survival fractions were investigated.Results After irradiation, compared with control group, the expression of nuclear EGFR protein increased in irradiated cervical carcinoma cell. Cetuximab inhibited the radiation_induced nuclear EGFR expression with decreased survival fractions.Conclusion Radiation could induce EGFR nuclear translocation in cervical carcinoma cell lines and nuclear EGFR might be correlated with radiation tolerance in Cervical carcinoma cell. |
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