| FANG Tong,GAO Hong.Clinical trial of low-dose whole body irradiation in the non_myeloablative hematopoietic stem cell transplantation[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):80-82 |
| Clinical trial of low-dose whole body irradiation in the non_myeloablative hematopoietic stem cell transplantation |
| Received:June 02, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.025 |
| KeyWords:Hematopoietic stem cell transplantation Non-myeloablative stem cell transplantation pretreatment Total body irradiation |
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| Abstract:: |
| Objective To observe the efficacy and acute toxicity in non-myeloablative low-dose tatal body irradiation. Methods From January 2006 to January 2008, 27 cases of hematopoietic stem cell transplantation patients received non_myeloablative pretreatment program involving low-dose whole body irradiation. Pretreatment program: the total dose of TBI was 2 Gy, once completely. According to primary disease, physical condition, age, organ function and HAL coincide situation, the patients received different chemotherapy, including FUL, CTX, Ara-C, melphalan and so on. To prevent the graft-versus-host disease (GVHD), CSA/MMF was used. Results Hematopoietic reconstruction: the peripheral blood WBC in all 27 cases reduced to (0.05-0.9)×109/L in 4 to 8 days, with the neutrophil count>0.5×109/L in 8 to 22 days (median+10.5 days), the platelet count> 30×109/L in 11 to 28 days (median+14.5 days). The transplant rate was 85.2% (23/27). The fever rate was 65% and the infection rate was 37%(10/27). Hemorrhagic cystitis,hepatic veno-occlusive disease (HVOD),and other complications did not occurred. 4 cases developed aGVHD (15%) and 5 cases developed cGVHD (19%) out of 27 cases. Follow-up 3 to 22 months, 21 cases are still alive(77.8%).Conclusion Pretreatment with low-dose whole body irradiation of non-myeloablative hematopoietic stem cell transplantation proved to be simple and safe with fewer complications and broad indications. Program of TBI with total dose of 2 Gy (once completely) is a safe, less toxic and effective method. It could achieve the effectiveness of immune suppression. |
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