| DAI Xiao-fang,WU Gang,LIU Li,et al.Research on forecasting values of the plasma levels for TGF-β, TNF-α and IL-10 in radiation pneumonitis[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):77-79 |
| Research on forecasting values of the plasma levels for TGF-β, TNF-α and IL-10 in radiation pneumonitis |
| Received:August 29, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.024 |
| KeyWords:Radiation pneumonitis Cytokines Forecasting value |
| FundProject: |
| Author Name | Affiliation | E-mail | | DAI Xiao-fang | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | | | WU Gang | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | | | LIU Li | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | liulixiehe2004@163.com | | YU Jie | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | | | DING Qian | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | | | KE Yang | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | | | 柯杨 | Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China | |
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| Abstract:: |
| Objective To study the relationship between plasma TGF-β, TNF-α, IL-10 levels and radiation pneumonitis (RP) in patients received thoracic irradiation with 3DCRT. Methods Sixty-nine patients of lung cancer stage Ⅲ or esophageal carcinoma were evaluated prospectively by ElISA for plasma TNF-α, TGF-β, IL-10 levels and IL-10/TNF-αbefore 3DCRT, after 40-50 Gy and after 3DCRT.Results Twenty-eight patients had RP. In RP patients, the plasma TGF-β, TNF-α, IL-10 levels and IL-10/TNF-αwas (15.2±13.4)μg/L,(28.4±13.4),(24.1±17.1) ng/L and 1.01±0.86 before 3DCRT, respectively; TNF-αincreased to (36.1±15.5) ng/L(t=2.01,P=0.040), IL-10 and IL-10/TNF-αdecreased to (18.8±10.8) ng/L (t=1.40,P=0.166)and 0.62±0.55 (t=1.90,P=0.063)after 40-50 Gy. After 3DCRT TNF-α was higher (36.9±15.5) ng/L than that before 3DCRT(t=-2.20,P=0.032),but IL-10 and IL-10/TNF-α were lower than that before 3DCRT [(13.7±6.2) ng/L, t=3.03, P=0.005;0.41±0.21,t=3.60,P=0.001]. TGF-β was not change in three times(P＞0.05).In non-RP patients, TGF-β,TNF-α, IL-10 and IL-10/TNF-αwas not yet change in three times(P＞0.05) respectively. TGF-β was not yet change between RP and non-RP patients before 3DCRT(t=0.54,P=0.594), and TNF-αwas higher in RP group than that in non_RP group after 40-50 Gy(t=2.02,P=0.048),but IL-10 and IL-10/TNF-α was less in RP group than that in non_RP group after 3DCRT(t=2.50,P=0.015;t=4.63,P=0.000). Conclusion The levels of TNF-α and IL-10 are closely related to the occurrence of RP. Monitoring the changes in dynamic state could predict the generation of RP, which could be employed as a sensitive index for indicating risks for acute RP. |
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