| LI Yong-heng,XU Bo,XU Xiao-na,WU Hao.Analysis of dosimetry and clinical outcome using intensity modulated radiation therapy for early breast cancer patients after breast conservative surgery[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):74-77 |
| Analysis of dosimetry and clinical outcome using intensity modulated radiation therapy for early breast cancer patients after breast conservative surgery |
| Received:January 10, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.023 |
| KeyWords:Breast neoplasms Breast conservative surgery Intensity modulated radiotherapy Conventional radiotherapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | LI Yong-heng | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | | | XU Bo | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | fangliaoxubo@vip.sina.com | | XU Xiao-na | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | | | WU Hao | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | | | 韩树奎 | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | | | 张珊文 | Department of Radiation Oncology, Peking University School of Oncology, Beijing Cancer Hospital& Institute, Beijing 100142, China | |
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| Abstract:: |
| Objective To analyze the dosimetric benefits,clinical effect and side-respond of whole breast using intensity modulated radiotherapy for early breastcancer after conservative surgery. Methods From Oct.2004 to Aug.2005,103 patients received the whole breast intensity modulated radiation therapy (IMRT). A dosimetric comparison of IMRT with conventional radiotherapy (CR) was performed on each patient. The cosmetic results, clinical effect and side-respond were observed. Results The average volume proportion of 95% and 107% prescribed dose was 95.8%±4.90% and 84.0%±20.7% (t=9.60,P<0.01) with IMRT and CR in clinical target volume, respectively. The V20 (lung volume of accepted>20 Gy/all lung volume×100%) of the ipsilateral lung were 15.70%±4.64% and 23.11%±7.88%(t=-13.3,P<0.01). The V30 of the heart were 4.44%±3.93% and 15.55%±10.89%(t=-11.3,P<0.01) with IMRT and CR respectively for sixty-three left side breast cancer patients. The 1- and 2-year excellent rate of good cosmetic outcome was both 100%. The 1-, 2- and 3-year local control rate was 99%,99% and 98%,respectively. The 1-, 2- and 3-year disease-free survival rate was 99%,99% and 96%,respectively. The Grade 1 and 2 acute radiation skin reaction rate was 95.1% and 4.9%,respectively.Conclusion Compared with conventional radiotherapy, IMRT improves dose distribution of CTV and reduce the dose of normal tissue around CTV; but with better clinical effects and lower side-respond for early breast cancer patients after breast conservative surgery. |
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