| XU Ya-ping,MA Sheng-lin,JI Yong-ling,et al.The analysis of effect about different therapies on brain metastases from non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):71-74 |
| The analysis of effect about different therapies on brain metastases from non-small cell lung cancer |
| Received:July 21, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.022 |
| KeyWords:Lung neoplasms Neoplasm metastasis Brain Combined modulated therapy Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | XU Ya-ping | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | | | MA Sheng-lin | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | mashenglin@medmail.com.cn | | JI Yong-ling | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | | | YU Yang | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | | | 俞洋 | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | | | 孙晓江 | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | | | 王升晔 | Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou 310022, China | |
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| Abstract:: |
| Objective To evaluate the prognostic factors of brain metastasis from non-small cell lung cancer and suggest a individualized treatment method proposal with prognostic estimation.Methods From Dec.2003 to Jan.2007, 183 patients received whole brain radiation therapy (WBRT) were retrospectively analyzed. Kaplan-Meier method was used to analyze the survival. Logrank test was used to evaluate the difference between the groups. Multivariate survival analysis was conducted using a Cox proportional hazard regression model with a backward stepwise procedure. Results The overall 1-, 2- and 3-year survival rate was 40.6%, 16.6% and 11.3%, respectively, but with a median survival time of 10.0 months (95% CI 8.6-11.4 months). In multivariate analysis, RAP grouping, weight loss, LDH in blood serum and treatment method were independent prognostic factors. The median survival time of WBRT alone, WBRT with chemotherapy, surgery with chemoradiotherapy and WBRT with Gefitinib was 9.0, 9.0, 22.0 and 13.0 months, respectively, but their difference were statistical significant (χ2=10.37, P=0.016). Conclusion The main prognostic factors of brain metastasis from non-small cell lung cancer are RAP grouping, weight loss, LDH in blood serum and treatment method. The survival time is prolonged by proper multidisciplinary management than WBRT alone. The effect of combined treatment of surgery with chemoradiotherapy is favorable for the patients operated with single region of metastasis. |
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