| ZHENG Hui,TU Xu-min,ZHEN Rong,et al.Effects of single and accumulative irradiation on ability of antioxidation and the antioxidase activity on rats[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):41-43 |
| Effects of single and accumulative irradiation on ability of antioxidation and the antioxidase activity on rats |
| Received:August 28, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.012 |
| KeyWords:Accumulative irradiation Nitric oxide Total ability of anti-oxidize antioxidase Superoxide dismutase Glutathion peroxidase Catalase Maleic dialdehyde |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHENG Hui | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | zhengningzh@163.com | | TU Xu-min | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | ZHEN Rong | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 张志兴 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | |
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| Abstract:: |
| Objective To compare the changes in nitric oxide (NO), total ability of anti-oxidize antioxidase, superoxide dismutase(SOD), glutathion peroxidase(GSH-PX), catalase(CAT)and maleic dialdehyde(MDA) in rats after single and accumulative 60Co γ-irradiation . Methods 48 rats were randomly divided into two groups of single and accumulative irradiation. Each group was irradiated by 60Co gamma-rays. The total irradiation doses were 0.4, 0.8, 1.6, 3.2 and 6.4 Gy, respectively in each group. The NO, total ability of anti-oxidize antioxidase, SOD, GSH-PX, CAT and MDA in serum were measured at day 1 after last irradiation.Results Compared with the single irradiation group, the NO (52.6-117.9μmol/ml), total ability of anti-oxidize antioxidase (3.3-26.2 U/ml), the antioxidase activity of the SOD (26.3-167.5 U/ml), GSH-PX (740.8-2462.4 U/ml), CAT (3.3-29.4 U/ml) and the content of MDA(29.3-155.1 nmol/ml) of rat serum in accumulative irradiation group were increased after irradiation, which was related with the accumulative irradiation dose. For instance, total ability of anti-oxidize antioxidase (26.2 U/ml), antioxidase activity of the SOD (167.5 U/ml) and CAT (29.4 U/ml) in 0.4 Gy group of accumulative irradiation were significantly increased when compared with those of control group. However, the content of MDA in accumulative irradiation group was obviously higher than that in single radiation group when the irradiation doses delivered over 3.2 Gy, which might be correlated with higher antioxidase activity. Conclusion Low dose of accumulative gamma-rays irradiation can induce the stimulative effect of antioxidase activity. However, higher dose of accumulative gamma-rays irradiation can damage the activity of antioxidase. |
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