| PAN Xiu-jie,YANG Zhi-hua,CAO Zhen-shan,et al.Distribution of uranium in rats inhaled with depleted uranium aerosols[J].Chinese Journal of Radiological Medicine and Protection,2009,29(1):23-26 |
| Distribution of uranium in rats inhaled with depleted uranium aerosols |
| Received:May 20, 2008 |
| DOI：10.3760/cma.j.issn.0254-5098.2009.01.007 |
| KeyWords:Depleted uranium Aerosols Inhalation |
| FundProject:国家自然科学基金资助项目(30271524);全军十一五科研基金资助项目(06Z031) |
| Author Name | Affiliation | E-mail | | PAN Xiu-jie | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | YANG Zhi-hua | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | CAO Zhen-shan | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | LI Ping | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | LIU Gang | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | WEI Han | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | WEI Han | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | | | ZHU Mao-xiang | Beijing Institute of Radiation Medicine, Academy of Military Medicine Science, Beijing 100850, China | zhumx@nic.bmi.ac.cn |
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| Abstract:: |
| Objective To investigate the distribution of uranium in rats after inhalation with depleted uranium aerosols.Methods The depleted uranium aerosols were inhaled by Wistar rats. At 30, 90, 180, 270, 360, and 540 d after inhalation, the rats were sacrificed and tissue samples were collected. The contents of uranium in lung, kidney, liver, heart, brain, thighbone, spleen and thymus were measured by laser time-dependent spectroscopy analysis.Results The uranium contents of lung increased in the high-dose and low-dose groups [(499 833.3±14 214.8) ng/g and (25 424.0±6193.4)ng/g, respectively] after inhalation, and significantly differed from the control (28.8±13.9)ng/g, (P<0.05).At 30 d after inhalation, the contents of uranium in lung, kidney and thighbone were higher than those of control, and then decreased time-dependently. At 60 d, the contents of uranium in liver, heart, brain, spleen and thymus were higher than those of control. Curve of the contents were biphasic, which went up first, reached at peak value and then went down. The contents of uranium were high in lung, thighbone, brain and thymus.Conclusion After inhalation of depleted uranium aerosols, lung and thighbone are the primary reservoirs for uranium redistributed, and accumulations in brain and thymus suggest other two organs for unanticipated injury by depleted uranium. |
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