| WANG Li-feng,PENG Rui-yun,HU Xiang-jun.Influence of microwave radiation on synapsin Ⅰ and its mechanism in cerebral cortex and hippocampus in Wistar rats[J].Chinese Journal of Radiological Medicine and Protection,2008,28(6):655-660 |
| Influence of microwave radiation on synapsin Ⅰ and its mechanism in cerebral cortex and hippocampus in Wistar rats |
| Received:November 20, 2007 |
| DOI： |
| KeyWords:Microwave Cerebral cortex Hippocampus Synapsin Ⅰ BDNF TrkB |
| FundProject:全军“十一五”医药卫生专项资助项目(06Z065) |
| Author Name | Affiliation | E-mail | | WANG Li-feng | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | PENG Rui-yun | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | pengry@nic.bmi.ac.cn | | HU Xiang-jun | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 高亚兵 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 王水明 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 李杨 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 徐新萍 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 董霁 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 高荣莲 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 马俊杰 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | | | 苏镇涛 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Corresponding authors: PENG Rui-yun, Email:pengry@nic.bmi.ac.cn | |
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| Abstract:: |
| Objective To investigate the effect of microwave irradiation on expressions of synapsin Ⅰ, BDNF and TrkB.Methods 40 Wistar rats were exposed to microwave with the average power density of 30 mW/cm2. RT-PCR and immunohistochemistry were used to study the change of the expressions of synapsin Ⅰ, BDNF and TrkB.Results Synapsin Ⅰ mRNA were increased at 6h and 1d (P<0.01), but decreased at 3dand 7d (P<0.01) in cerebral cortex. It was increased at 6h and 1d (P<0.01) in hippocampus after radiation. The expression of BDNF was increased progressively in 6h-3d (P<0.01 or P<0.05) in cerebral cortex and in 1-7d (P<0.01 or P<0.05) in hippocampus. BDNF mRNA was increased at 6h (P<0.01), decreased at 1d (P<0.01), then increased at 3d and 7d (P<0.01 or P<0.05) after radiation in cerebral cortex. It was increased at 1d (P<0.01) in hippocampus. The expression of TrkB was increased in 1-3d (P<0.01) in cerebral cortex and in 3-7d (P<0.01) in hippocampus after radiation. TrkB mRNA was increased at 6h and 7d (P<0.01) in cerebral cortex, decreased at 6h, 3d and 7d (P<0.01 or P<0.05) in hippocampus after radiation.Conclusions Microwave radiation can induce the abnormity of expressions of synapsin Ⅰ, BDNF and TrkB in cerebral cortex and hippocampus, which might play a role in the injury and repair of synaptic transmission. |
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