| CHEN Jin-hu,LI Bao-sheng,LU Jie.Applying SPECT to protection of lung function for lung cancer patients with radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2008,28(6):646-649 |
| Applying SPECT to protection of lung function for lung cancer patients with radiotherapy |
| Received:November 21, 2007 |
| DOI： |
| KeyWords:Lung neoplasms/radiotherapy Tomography,single-photon emission computed Image fusion Plan optimization |
| FundProject:山东省科技攻关计划(2006GG2202012) |
| Author Name | Affiliation | E-mail | | CHEN Jin-hu | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | LI Bao-sheng | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | LU Jie | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | 尹勇 | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | yinyongsd@yahoo.com.cn | | 王中堂 | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | | | 董晓玲 | Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China | |
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| Abstract:: |
| Objective To study on the feasibility of making radiotherapy plan for lung cancer patients combined with single-photon emission computed tomography (SPECT) images to effectively protect the functional lung.Methods Eleven lung cancer patients were selected and carried out with SPECT under the same body posture after CT simulation. The images of SPECT and CT were fused with treatment planning system (TPS), and the outline of the functional-lung on CT image by fusion image was drawn. Through application of TPS, optimized parameters were setup to compare two plans (T1 and T2). The distribution of lung function was not considered in T1 plan, while it was fully considerd in T2 plan to reduc the exposure dose on functional lung by all means. The restricted parameters were set respectively on spinal cord, heart and other organs. Radiotherapy total doses were 60 Gy with 2 Gy per fractionation.Results On the premise of ensuring the prescription dose up to par for planning target volume (PTV) also which no difference and/or spinal cord maximal dose <45 Gy, the volumes under 5 Gy, 10 Gy and 20 Gy (V5, V10 and V20) of functional-lung reduced in T2 plan (P<0.05), there were (63.45±4.20)%、(48.45±3.87)%、(22.66±2.01)% in T1 plan, and (61.51±4.05)%、(40.93±3.23)%、(19.45±1.74)% in T2 plan, respectively. But the V30, V40 and V50 did not go down (P>0.05), there were (13.34±1.67)%、(7.83±1.18)%、(4.14±0.68)% in T1 plan and (12.69±1.54)%、(8.10±1.30)%、(4.53±0.82)% in T2 plan, respectively.Conclusion It can effectively reduce the radiation dose on functional lung, decrease complications, and improve living quality of the lung cancer patients at plan optimization combined with SPECT images. |
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