| LIANG Qi-lian,ZHANG Ying,LAI Zhen-nan.The level change of serum soluble Fas for non-small cell lung cancer patients with concurrent radio-chemotherapy[J].Chinese Journal of Radiological Medicine and Protection,2008,28(6):628-631 |
| The level change of serum soluble Fas for non-small cell lung cancer patients with concurrent radio-chemotherapy |
| Received:December 10, 2007 |
| DOI： |
| KeyWords:Lung neoplasms/radio-chemotherapy Serum soluble Fas Enzyme linked immunosorbent assays |
| FundProject:广东省医学科研课题基金资助项目(B1999138) |
| Author Name | Affiliation | E-mail | | LIANG Qi-lian | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | lianqilian@gdmc.edu.cn | | ZHANG Ying | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | LAI Zhen-nan | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | 蔡良真 | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | 黄杰 | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | 李土华 | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | 罗海清 | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | | | 杨勤 | Center of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China | |
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| Abstract:: |
| Objective Study on the change of serum soluble Fas (sFas) level and prognostic relation for non-small cell lung cancer(NSCLC) patients with concurrent radio-chemotherapy using enzyme linked immunosorbent assays(ELISA).Methods Sixty patients were obtained. The sFas level were compared before treatment with one month after treatment, and healthy donors were used as controls level of sFas. The sFas level of before treatment were compared treatment efficiency patients(complete remission and partial remission, 50 patients) and treatment inefficiency patients(no change and progressive disease, 10 patients). The correlation was analyzed between 2-year survival NSCLC patients and their sFas level.Results The sFas level before treatment in NSCLC patients was obviously higher than healthy controls (8.55±0.63) ng/L and (6.03±0.55) ng/L; (t=18.63,P<0.01), with 1 month after treatment obviously lower than before treatment in NSCLC patients (7.24±0.52) ng/L and (8.55±0.63) ng/L;(t=12.44,P<0.01). The sFas level of before treatment was treatment efficiency patients obviously lower than treatment ineffectived patients (8.02±0.43)ng/L and (8.97±0.42)ng/L; (t=8.67,P<0.01),with 2-year survival patients obviously(26 patients)lower than shortage 2-year survival patients(34 patients)(t=645.88,P<0.05).Conclusions Concurrent radio-chemotherapy can reduce sFas level in NSCLC patients, the changes of sFas level before and after treatment may provide worth prognostic for NSCLC patients. |
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