| QI Xue-song,LÜ Hui-min,WANG Chun-yan,et al.Preliminary study on serum levels of IL-2, IL-6 and TNF-α and their gene polymorphism in copper miners[J].Chinese Journal of Radiological Medicine and Protection,2008,28(6):576-578 |
| Preliminary study on serum levels of IL-2, IL-6 and TNF-α and their gene polymorphism in copper miners |
| Received:July 31, 2008 |
| DOI： |
| KeyWords:Copper mien IL-2 IL-6 TNF-α Gene polymorphism |
| FundProject:科技部科研院所社会公益研究专项(2005DIB1J087) |
| Author Name | Affiliation | E-mail | | QI Xue-song | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | suxu@nirp.cn | | LÜ Hui-min | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | WANG Chun-yan | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 张伟 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 郝述霞 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 孙全富 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 苏旭 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | |
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| Abstract:: |
| Objective To study biologic effect of high radon exposure in non-uranium miners by measurements of serum levels of IL-2, IL-6 and TNF-α and study on their gene polymorphism.Methods Serum levels of IL-2, IL-6 and TNF-α in the miners selected from a Yunnan-based copper mine were measured by ABC-ELISA. TNF-α (-308,G→A) genotypes were identified by RFLP-PCR, IL-2 (-330, T→G) genotypes by sequence analysis.Results Compared the miners with its control group, there were no statistical significance of the concentrations of serum IL-2 (F=0.71, P>0.05), IL-6 (F=1.09, P>0.05) and TNF-α (F=0.95, P>0.05). Frequencies of IL-2 (-330, T→G) genotypes (χ2=0.02, P>0.05) and TNF-α (-308, G→A) genotype (χ2=2.21, P>0.05) were shown no statistical significance too.Conclusions Compared with the control group, concentrations of serum IL-2, IL-6 and TNF-α in miners working in the copper mine was lower, frequencies of genotypes of TNF-α (-308,A A) was higher in the miners. But all the differences were not statistical significant. |
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