| SHEN Wen-bin,ZHU Shu-chai,LI Juan.Prognostic effect of clinical staging for esophageal carcinoma patients with three-dimensional conformal radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2008,28(4):371-374 |
| Prognostic effect of clinical staging for esophageal carcinoma patients with three-dimensional conformal radiotherapy |
| Received:February 25, 2008 |
| DOI： |
| KeyWords:Esophageal neoplasm Radiotherapy Neoplasm staging Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | SHEN Wen-bin | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | ZHU Shu-chai | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | wbshen1979@sina.com | | LI Juan | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 苏景伟 | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 王玉祥 | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 李任 | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 邱嵘 | Department of Radiation Oncology, The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective To study the prognostic factors in esophageal cancer patients after three-dimensional conformal radiotherapy(3DCRT) using Cox proportional hazard model and to evaluate the validity of the clinical staging.Methods Eight-one esophageal carcinoma patients treated by 3DCRT were analyzed retrospectively, and several factors including the local T staging of tumor, N staging and the clinical staging were analyzed using Cox proportional hazard model. The correlation of the local T staging of tumor and the clinical staging with prognosis was studied.Results The 1-,2-,3- and 4-year overall survival rate was 67.9%, 45.7%, 40.5% and 30.9%, respectively. The 1-,2-,3-,4-year local control rate was 83.0%, 76.1%, 73.9% and 69.8%, respectively. Multivariate analysis showed that the size of tumor, the local T staging of tumor, the clinical stage and esophageal GTVD95 were independent prognostic factors. There were significant differences between the local T staging of tumor and the clinical staging in terms of overall survival, local-regional control, distant metastasis-free survival and disease-free survival(all P<0.05). There were significant differences between stage Ⅲ and stage Ⅳ in terms of overall survival, distant metastasis-free survival and disease-free survival(P=0.020,0.039,0.045), except for the local-regional control(P=0.155). The stage N0 had the same results with stage N
1,and N2.Conclusions The four-stage system is optimal for non-operative esophageal cancer in clinical staging and it can be used to predict prognosis. |
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