| WU Zhi-bing,MA Sheng-lin,ZHANG Ai-qin,et al.Experimental study on the prevention and treatment of acute radiation lung injury of rats by Tanreqing injection[J].Chinese Journal of Radiological Medicine and Protection,2008,28(4):364-367 |
| Experimental study on the prevention and treatment of acute radiation lung injury of rats by Tanreqing injection |
| Received:February 25, 2008 |
| DOI： |
| KeyWords:Radioactive lung injury Cytokine Hydroxyproline Tanreqing |
| FundProject: |
| Author Name | Affiliation | E-mail | | WU Zhi-bing | Department of Radiation Oncology, Zhejiang Cancer Hospital, Key Laboratory of Traditional and Western Oncological Medicine of Zhejiang Province, Hangzhou 310022, China | | | MA Sheng-lin | Department of Radiation Oncology, Zhejiang Cancer Hospital, Key Laboratory of Traditional and Western Oncological Medicine of Zhejiang Province, Hangzhou 310022, China | mashenglin@medmail.com.cn | | ZHANG Ai-qin | Department of Radiation Oncology, Zhejiang Cancer Hospital, Key Laboratory of Traditional and Western Oncological Medicine of Zhejiang Province, Hangzhou 310022, China | | | 孔祥鸣 | Department of Radiation Oncology, Zhejiang Cancer Hospital, Key Laboratory of Traditional and Western Oncological Medicine of Zhejiang Province, Hangzhou 310022, China | |
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| Abstract:: |
| Objective To observe the effect of Tanreqing on preventing and treating acute radiation injury of rats'lung tissue. Methods Sixty Wistar female rats were randomly allocated into 4 groups as blank control group, model group, Tanreqing treatment group and dexamethasone combined cefalexin treatment group. Each group had 15 rats. The lungs of all rats except those in the blank group were irradiated by 6 MV X ray linear accelerator with the dose of 25 Gy. 5 rats in each group were randomly chosen at each time point (2, 4 and 6 weeks after irradiation). The cytokine in the arterial blood was detected. The neutrophil number was counted in the BALF. The content of hydroxyproline of the right lung was measured. The pathological changes of the right lung dyed with HE stain were observed through light microscope at the same time. Results The lung tissue of rats in model group had radiation pneumonia changes 2 weeks after irradiation. The lung stroma was obviously thickened and much cellulose effused in pulmonary alveoli 6 weeks after irradiation. Except for the blank group, radiation pneumonia of rats in Tanreqing treatment group was the slightest, the number of neutrophil of BALF was lower than that of the other two control groups. TNF-α,TGF-β1 of blood serum and hydroxyproline of lung tissue in Tanreqing treatment group were lower than those of the model group. Conclusions Tanreqing can inhibit the expression of inflammatory factors and fibrosis-inducing factors, and thus lessen the inflammatory reaction of the early stage of radiation pneumonia. And it can prolong the progression of radiation lung fibrosis. Tanreqing has an important role in preventing and treating the acute radiation lung injury. |
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