| ,et al.Toxicological effect of long-term exposure to mixed dust containing radiothorium rare earth on workers[J].Chinese Journal of Radiological Medicine and Protection,2008,28(4):332-334 |
| Toxicological effect of long-term exposure to mixed dust containing radiothorium rare earth on workers |
| Received:October 25, 2007 |
| DOI： |
| KeyWords:Comet assay Micronucleus formation Radiation Toxicology effect |
| FundProject:科技部科研院所社会公益研究专项项目(2005DIB1J087);公共卫生专项经费(54006-0104) |
| Author Name | Affiliation | E-mail | | 吕慧敏 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 贾珂君 | 包头钢铁(集团)有限责任公司劳动卫生职业病防治研究所 | | | 张翠兰 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 王春燕 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 齐雪松 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 涂序珉 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 王平 | 包头钢铁(集团)有限责任公司劳动卫生职业病防治研究所 | | | 苏旭 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | suxu@nirp.cn | | 孙全富 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | |
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| Abstract:: |
| Objective To investigate the toxicological effects of long-term exposure to mixed dust containing radiothorium rare earth on workers.Methods Single cell gel electrophoresis was used to examine the DNA comet length of peripheral blood lymphocytes, and then to evaluate the DNA damage degree according to the comet length. The lymphocyte cell method was used to examine the micronucleus formation rate of peripheral blood lymphocyte. Lung function instrumental MiCROSPRO HI-198 was used to determine the lung ventilation function.Result For exposure group and control group,the average values of comet length were (40.2±4.14) μm and (39.5±2.54) μm, respectively, while the frequency of micronucleus formation were (2.71±2.04)‰ and (0.79±0.91)‰. The lung function barrier formation were 70.9% and 64.9%, which means the exposure group was higher than that of control.Conclusions Mine mixed dust containing radiothorium rare earth may have certain toxicology effects on the professional workers. |
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