| XIA Ying,SUN Quan-fu,SHANG Bing,et al.Polymorphisms of the cytochrome P450 and glutathion s-transferase genes associated with lung cancer susceptibility for the residents in high radon-exposed area[J].Chinese Journal of Radiological Medicine and Protection,2008,28(4):327-332 |
| Polymorphisms of the cytochrome P450 and glutathion s-transferase genes associated with lung cancer susceptibility for the residents in high radon-exposed area |
| Received:March 27, 2008 |
| DOI： |
| KeyWords:Tumoe susceptibility Radonexposure Lung cancer CYP1A1 GSTm1 Genetic polymorphism |
| FundProject:国家自然科学基金资助项目(30470530;39970235) |
| Author Name | Affiliation | | XIA Ying | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | SUN Quan-fu | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | SHANG Bing | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 吕慧敏 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 冯顺治 | 甘肃省庆阳市人民医院 | | 程同心 | 甘肃省庆阳市地方病防治协调小组办公室 | | 崔宏星 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 齐雪松 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 王利平 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 王浩 | 甘肃省庆阳市人民医院 | | 孙粉珍 | 甘肃省庆阳市人民医院 | | 王海军 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 巨雅洁 | 甘肃省庆阳市人民医院 | | 毛玲 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China | | 王琳 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Bejing 100088, China |
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| Abstract:: |
| Objective To investigate whether the CYP1A1 and GSTm1 genetic polymorphism are assoaiate with lung cancer in the residents of high radon exposure area.Methods A case-control method was performed, lung cancer and control individials were selected from Qingyang county of Gansu Province.The indoor radon and thoron concentration were measured, CYP1A1 and GSTm1 genetic polymorphism were detected by PCR-RFLP or multiplex-PCR.Results The risk of developing lung cancer for people carried with heterozygous CYP1A1(w/m)and mutation genotype GSTm1(-)were 1.46(95% CI 0.72-2.95) and 1.28(95% CI 0.67-2.41) higher than wide type, respectively.The risk of lung carcer for combination of CYP1A1 (w/m)and GSTm1 (-)increased to 2.00 fold (95%CI 0.72-5.58),the heavy smokers who carried with heterozygous of CYP1A1(w/m)was 2.14 fold (95%CI 0.35~13.12). People who carried with heterozygous CYP1A1(w/m) or GSTm1(-) when effective dose was in 50-100 mSv,lung canser risk will rised to 2.63 fold (95% CI 0.21-31.34) and 3.50 fold(95% CI 0.31-39.12). The risk of lung cancer for people from tumors family was 3.75 fold(95%CI 1.51-9.29) with statistic significance.Conclusions The CYP1A1 (w/m)and GSTm1 (-) are two more risk factors for lung carcer,specifically when effective dose was in 50_100 mSv and the two gene functions combined together. |
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