| XIA Guang-rong,LIU Gui-mei,JIN Guo-hua,et al.Clinical study of radiotherapy in bone metastases of lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2008,28(3):262-264 |
| Clinical study of radiotherapy in bone metastases of lung cancer |
| Received:November 26, 2007 |
| DOI： |
| KeyWords:Neoplasms Bone metastases Pain relief Radiotherapy Outcome |
| FundProject: |
| Author Name | Affiliation | | XIA Guang-rong | Department of Radiation Oncology, Beijing Chest Hospital, Beijing 101149, China | | LIU Gui-mei | Department of Radiation Oncology, Beijing Chest Hospital, Beijing 101149, China | | JIN Guo-hua | Department of Radiation Oncology, Beijing Chest Hospital, Beijing 101149, China | | 李雪冰 | 北京结核病胸部肿瘤研究所北京胸科医院放疗科, 综合科 |
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| Abstract:: |
| Objective To evaluate the efficacy of radiotherapy on bone metastases of lung cancer. Methods 189 patients with painful bone metastasis were investigated retrospectively from January 2000 to November 2006. There were two radiotherapy groups in this study. Conventional fractionation group was 2 Gy/fraction/day, 5 days/week to 30-50Gy,including 163 tumors. The middle fractionation and hypofraction group was 3-5Gy/fraction/day, 2-3 days/ week to 20-40Gy, including 58 tumors. Subgroup analysis were used for radiotherapy responses according to pathologic type and primary tumor control status. Results The response rates were 90.7% and 87.9% (χ2=1.229, P>0.05), respectively, in conventional fractionation, middle fractionation and hypofractionation groups while the overall response rate was 90.0%. In subgroup analysis, the response rates were 92.4% and 89.0% (χ2=0.668, P>0.05), respectively in small cell lung cancer and non- small cell lung cancer. The response rates were 88.4% and 91.7% (χ2=0.787,P>0.05) in controlled primary tumor and not controlled primary tumor subgroups. Conclusions Radiotherapy is effective and could be the first option that can relieve bone pain in bone metastasis of lung cancer. However, different dose-fractionation, different pathologic type and primary tumor control status have no significant impact on effect of radiotherapy. |
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