| CAI Yong,LI Dong-ming,SUN Yan,et al.Clinic study of CMNa radiosensitivity enhacement on malignant tumors[J].Chinese Journal of Radiological Medicine and Protection,2008,28(3):260-261 |
| Clinic study of CMNa radiosensitivity enhacement on malignant tumors |
| Received:October 29, 2007 |
| DOI： |
| KeyWords:CMNa Radiotherapy Malignant tumors |
| FundProject: |
| Author Name | Affiliation | | CAI Yong | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | LI Dong-ming | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | SUN Yan | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 苏星 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 刘长青 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 肖绍文 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 铁剑 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 徐博 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China | | 张珊文 | Department of Radiation Oncology, Peking University the School of Oncology, Beijing 100036, China |
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| Abstract:: |
| Objective To evaluate the effects and safety of CMNa on radiosensitivity enhacement for malignant tumors. Methods According to the standard protocol of CMNa Ⅳ stage clinic trial, 80 patients with malignant tumors were treated with 3DCRT or conventional radiotherapy, 2 Gy/fraction and five fractions weekly. Concomitance CMNa were applied in intravenous 800 mg/m2, three times weekly. The treatment effects and side-effects were observed. Results The curative effect rates were 91.7% for cervical cancer, 85.7% for nasopharynx cancer, 66.7% for esophageal cancer, 54.5% for lung cancer, 40% for liver and gall cancer. The total curative effect rate was 62.6% and the tumor control rate was 100%. The side-effects occurrence rates of mucosa and skin which were grades 1 to 2, were 51.3% and 46.3%,respectively,which were the highest in all side-effects. There were no statistical significances between before and after treatment on the side-effects and blood test. Conclusions CMNa combined with radiotherapy can enhance the control rates of tumors with low toxicity and high safety. |
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