| ZHANG Wei.Study of chromosome aberrations on the workers occupationally exposed to thorium and rare earth mixed dust[J].Chinese Journal of Radiological Medicine and Protection,2008,28(3):242-244 |
| Study of chromosome aberrations on the workers occupationally exposed to thorium and rare earth mixed dust |
| Received:June 15, 2007 |
| DOI： |
| KeyWords:Occupational exposure Thorium and rare earth mixed dust Lymphocyte Chromosome aberration |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHANG Wei | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 王春燕 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 吕慧敏 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 贾柯君 | 包钢劳动卫生职业病防治研究所 | | | 刘玉飞 | 包钢劳动卫生职业病防治研究所 | | | 张翠兰 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 郝述霞 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | 苏旭 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | suxu@nirp.cn |
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| Abstract:: |
| Objective To study the effect of thorium and rare earth mixed dust on chromosome aberrations in the lymphocytes of occupational exposed workers. Methods Analyses of unstable chromosome aberrations on 53 occupational exposed workers and 58 control workers were carried out by the conventional Giemsa staining method. Fluorescence in situ hybridization method was performed to analyze the chromosome stable aberrations on 10 occupational exposed workers and 10 control workers. Results The frequencies of chromosomal aberration cells, dicentrics plus rings, total aberrations in exposed workers were significantly higher than those in controls. No significant difference was found in the frequency of acentric aberrations between exposed and non-exposed workers. No significant difference was found in the frequency of translocations between exposed and non-exposed workers. Conclusions Chronically occupational exposure to thorium and rare earth mixed dust can increase the induction of unstable chromosome aberration, but the increase of stable chromosome aberrations (translocation) can not be observed. |
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