| LIU Qing-jie,FENG Jiang-bin,LU Xue.Adaptive responses on chromosome aberration and DNA breakage of peripheral lymphocytes from workers exposed to thorium and rare earth mixed dust in Baotou Steel Plant[J].Chinese Journal of Radiological Medicine and Protection,2008,28(3):235-238 |
| Adaptive responses on chromosome aberration and DNA breakage of peripheral lymphocytes from workers exposed to thorium and rare earth mixed dust in Baotou Steel Plant |
| Received:June 12, 2007 |
| DOI： |
| KeyWords:Thorium and rare earth mixed dust Chromosome aberration Single cell gel electrophoresis Adaptive response |
| FundProject: |
| Author Name | Affiliation | E-mail | | LIU Qing-jie | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | FENG Jiang-bin | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | LU Xue | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | 陈德清 | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | 刘玉飞 | 包钢劳动卫生职业病防治研究所 | | | 贾柯君 | 包钢劳动卫生职业病防治研究所 | | | 吕慧敏 | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | | 苏旭 | National Institute for Radiological Protection, China CDC, Beijing 100088, China | suxu@nirp.cn |
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| Abstract:: |
| Objective To explore if the occupational exposure to low dose thorium could induce adaptive response in peripheral lymphocytes. Methods 40 individuals, who exposed to thorium and rare earth mixed dust (exposure group) or control in Baotou Steel Plant, were selected, and chromosome aberrations were analyzed. Then the peripheral blood samples were irradiated in vitro with 2 Gy 60Coγ-rays, and unstable chromosome aberration or DNA stand breakage analysis using single cell gel electrophoresis was performed. Results The dicentrics before 2Gy exposure in exposure group was higher than that in control (P0.05). But the dicentrics after 2Gy exposure in exposure group was lower than that in control, but not significantly (P>0.05). The tricentrics in exposure group was significantly lower than that in control (U=3.1622,0.001t=25,P<0.001). Conclusions Occupational exposure to low dose thorium could induce the adaptive response on chromosome aberration and DNA strand breakage in peripheral lymphocytes. |
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