| LI Jian-bin,LU Jie,FAN Ting-yong.Comparison of different treat ment plannings for whole breast irradiation with tumor bed boost after breast-conservative surgery[J].Chinese Journal of Radiological Medicine and Protection,2008,28(2):163-166 |
| Comparison of different treat ment plannings for whole breast irradiation with tumor bed boost after breast-conservative surgery |
| Received:March 12, 2007 |
| DOI： |
| KeyWords:Breast-conservative surgery Conventional radiotherapy Intensity-modulated radiotherapy Tumor bed boost Treatment planning |
| FundProject:山东省科技攻关资助项目(012130141) |
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| Abstract:: |
| Objective To explore the difference of conformity and homogeneity of dose distribution in the whole breast and tumor bedtargets and dose-volume parameters of the irradiated heart, lung and contralateral breast between the different treatment plannings for whole breast irradiation with tumor bed boost after breast-conservative surgery. Methods Twelve left-side breast cancer patients received breast-conservative surgery with negative axillary lymph node and with silver slips set inthe cavity were selected. The different plannings including conventional radiotherapy (CRT), forward intensity-modulated radiotherapy with no lung block segments (IMRT-F), forward intensity-modulated radiotherapy with lung block segments (I MRT-F-L) and si multaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) were completedfor each patient. The difference of conformity and homogeneity of dose distributioninthe whole breast andtumor bed targets, the relatedirradiated dose-volume parameters of the ipsilateral lung, heart and contralateral breast were compared among the different plannings.Results There were statistical differences of the ratios of breast volume contained by the prescribed dose given to PTV1(Vdose-PTV1)to VPTV1, volume of PTV1 contained by the prescribed dose givento PTV1(V PTV1-dose) to VPTV2, conformal index of PTV1(CIPTV1) and conformal index of PTV2(CIPTV2) among the different plannings. The volume of the lung which received more than 20 Gy(V20) in CRT planning was statistically higher those that in three I MRT plannings, but there was no significant difference among three types of IMRT. The dose irradiatedto the heart in the CRT planning was significantly higher thanthat in IMRT-F, IMRT-F-L and SIB-I MRT planning. Dmax and Dmean in the contralateral breast for CRT plan were significantly higher than those inthree types of I MRT plannings, but with no significant difference of Dmax and Dmean among three types of I MRT plannings. Conclusions Comparing the different types of treatment plannings for whole breast irradiation with tumor bed boost for the patients with left breast cancer after breast-conservative surgery, I MRT-F, I MRT-F-L and SIB-IMRT plannings are all statistically superior to CRT planning, but there are no statistical differences among three types of I MRT plannings except some other parameters. |
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