| LIAO An-yan,WANG Jun-jie,JIANG Yu-liang,et al.3-Dimensional conformal radiotherapy and paclitaxel radiosensitization combined with chemotherapy on locally advanced non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):69-71 |
| 3-Dimensional conformal radiotherapy and paclitaxel radiosensitization combined with chemotherapy on locally advanced non-small cell lung cancer |
| Received:March 28, 2007 |
| DOI： |
| KeyWords:Locally advanced non-small cell lung cancer 3-dimesional conformal radiotherapy Paclitaxel Chemotherapy Prognosis |
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| Abstract:: |
| Objective To evaluate the efficacy and side-effect of 3-Dimensional conformal radiotherapy(3-DCRT) and paclitaxel radiosensitization combined with or without chemotherapy on locally advanced non-small cell lung cancer (NSCLC). Methods Fifty cases of stage ⅢA and ⅢB NSCLC were treated with 3-DCRT and paclitaxel radiosensitization, including 27 patients combined with chemotherapy(group 1) and 23 patients without chemotherapy(group 2). They were given chest 3-DCRT at 3-4 Gy/d for 5 d/week till a total dose of 60-70 Gy within 4-5 weeks. Before fractionated irradiaion weekly, paclitaxel chemotherapy was administered at first with the dose of 30-40 mg/m2 for 3 h by infusion . The chemotherapy regimen is paclitaxel 135 mg/m2 by intravenous infusion at days 1, 8 and cisplatin 75 mg/m2 by intravenous infusion at days 2-4. The treatment was repeated every 28 days, up to 3-6 courses. Results The overall response rates(CR+PR) in group 1 and group 2 were 88.8% and 60.8%,respectively (P<0.05). The median survival time were 21 and 16 months in respectively. The 1-, 2-, and 3-year survival rates were 74.1%, 40.7%, 19.1%, and 64.7%, 20%, 10%, respectively (P<0.05). The main toxicities of granulo-cytopenia were 85.2% and 43.5%,repectively (P<0.05). Conclusions Weekly low dosage of paclitaxel with concurrent 3-DCRT combined with chemotherapy might be tolerable and promising in the treatment of locally advanced NSCLC. |
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