| FANG Tong,GAO Hong,SUN Bao-jin,et al.Clinical analysis of hematopoiesis reconstruction after total body irradiation in hematopoietic stem cell transplantation[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):66-68 |
| Clinical analysis of hematopoiesis reconstruction after total body irradiation in hematopoietic stem cell transplantation |
| Received:August 13, 2007 |
| DOI： |
| KeyWords:Hematopoietic stem cell transplantation Autologous and allogeneic Peripheral blood stem cell transplant Bone marrow transplant Hematopoiesis reconstruction Total body irradiation |
| FundProject: |
| Author Name | Affiliation | | FANG Tong | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | GAO Hong | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | SUN Bao-jin | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | 陈力 | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China |
|
| Hits: 3057 |
| Download times: 2016 |
| Abstract:: |
| Objective To analyze the clinical outcome of total body irradiation in hematopoiesis reconstruction after autologous and allogeneic hematopoietic stem cell transplantation. Methods 35 patients received autologous hematopoietic stem cell transplantation (ASCT group )and 35 patients received allogeneic hematopoietic stem cell transplantation (Allo-HSCT group) were enrolled in this study. And their hematopoiesis reconstruction were observed and analyzed. Results The recovery time of ANC were 14 and 16 d, respectively, and the recovery time of PLT were 23 and 27 d, respectively, the difference were not significant (P>0.05) in ASCT group and Allo-HSCT group. But for both group, hematopoiesis reconstruction were faster in peripheral blood stem cell transplant than those in bone marrow transplant(P<0.05). The recovery time of PLT with the patients of total body irradiation dose ≥10 Gy were longer than those of <10 Gy.Conclusions At the same doses, the clinical outcome of hematopoiesis reconstruction of ASCT is similar to that of Allo-HSCT. But the recovery time in peripheral blood stem cell transplantation is faster than that in bone marrow transplant. The recovery time of PLT has relation with the irradiation dose. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
