| SUN Yan,ZHENG Bao-min,WU Hao,et al.Phase Ⅰ study of concurrent chemotherapy and intensity modulated radiotherapy (IMRT) in locally advanced nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):63-65 |
| Phase Ⅰ study of concurrent chemotherapy and intensity modulated radiotherapy (IMRT) in locally advanced nasopharyngeal carcinoma |
| Received:December 04, 2006 |
| DOI： |
| KeyWords:Nasopharyngeal carcinoma Intensity modulated radiotherapy(IMRT) Concomitant radiochemotherapy Early toxicity |
| FundProject: |
| Author Name | Affiliation | | SUN Yan | Peking University School of Oncology, Beijing 100036, China | | ZHENG Bao-min | Peking University School of Oncology, Beijing 100036, China | | WU Hao | Peking University School of Oncology, Beijing 100036, China | | 韩树奎 | Peking University School of Oncology, Beijing 100036, China | | 徐博 | Peking University School of Oncology, Beijing 100036, China | | 朱广迎 | Peking University School of Oncology, Beijing 100036, China | | 张珊文 | Peking University School of Oncology, Beijing 100036, China |
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| Abstract:: |
| Objective To determine the early toxicity of treatment in the patients with locally advanced nasopharyngeal carcinoma receiving IMRT with concurrent chemotherapy.Methods From Aug 2004 to March 2006, 20 patients were treated with IMRT and concurrent chemotherapy for nasopharyngeal carcinoma(stage Ⅲ-Ⅳa) in Peking University School of Oncology. The median total dose to the gross tumor volume and the clinical target volume was 70.8 and 61.5 Gy, respectively. The protocol of concomitant chemotherapy used in this study was 3 cycles of cisplatin plus fluorouracil. There were four dose-level groups in the study. Treatment related toxicities were scored according to the common toxicity criteria (NCI-CTC Version 2.0).Results The median follow-up period for all patients was 16.5 months. No evidence of local recurrence for them was observed. Two patients had distant metastasis on the eighth month and the eighteenth month after beginning concurrent radiochemotherapy. Complete response and partial response were observed on MRI or CT scan at the end of treatment in 20% and 75% patients, respectively. One patient had no response. In the patients with concurrent chemotherapy, radiation induced side-effect of mucous membrane of mouth was significantly associated with dose level of chemotherapy. Conclusions Toxicities related to the treatment are significantly associated with the dose level of chemotherapy. Toxicities of the combination of IMRT and chemotherapy should be controlled by less than 30% to 40% for Grade 3, and 10% for Grade 4. |
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