| ZHU Li-hong,SU Xing,WU Hao,et al.Dosimetry of bone marrow irradiated by intensity modulated whole pelvis radiotherapy for cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):57-60 |
| Dosimetry of bone marrow irradiated by intensity modulated whole pelvis radiotherapy for cervical cancer |
| Received:May 26, 2007 |
| DOI： |
| KeyWords:IMRT Pelvic bone marrow Cervical cancer Hematologic toxicity |
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| Abstract:: |
| Objective To assess the effect of applying intensity modulated whole pelvis radiotherapy(IM-WPRT) on reducing the irradiated volume of pelvic bone marrow (BM).Methods 15 consecutive patients with cervical cancer underwent IM-WPRT. The clinical target volume(CTV) and the planning target volume (PTV＝CTV＋1.0 cm) and pelvic BM were contoured. Two plans were created for each patient: an IM-WPRT treatment plan (excluding pelvic BM), and a pelvic BM-sparing (BMS) IM-WPRT plan. Dose-volume histograms for the PTV and critical organs were evaluated.Results BMS IM-WPRT treatment plans demonstrated a significant reduction of the volume of pelvic BM at various dose levels, especially at 20-50Gy(P≤0.008).Compared with the conventional IM-WPRT, BMS IM-WPRT decreased the BM volume by 6.5% and 8.8% at 80% and 100% of the prescription dose,respectively. Furthermore, the BMS IM-WPRT plans,with adequate coverage and the same dose homogeneity of PTV, resulted in significant sparing of other critical organs.Conclusions BMS IM-WPRT is superior to pelvic BM. It provides dosimetric evidence of reducing hematologic toxicity of concurrent radiochemotherapy in locally advanced cervical cancer. |
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