| WANG Zhi-dong,CHEN Xiao-hua,DONG Bo,et al.Changes in haptoglobin of whole-body-irradiated mice by γ-rays[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):52-55 |
| Changes in haptoglobin of whole-body-irradiated mice by γ-rays |
| Received:April 03, 2007 |
| DOI： |
| KeyWords:γ-ray Serum Haptoglobin |
| FundProject: |
| Author Name | Affiliation | E-mail | | WANG Zhi-dong | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | CHEN Xiao-hua | Beijing Institute of Radiation Medicine, Beijing 100850, China | chenxh@nic.bmi.ac.cn | | DONG Bo | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 侯丽莉 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 张军权 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 饶亚岚 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 高荣莲 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 高玲 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 丛悦 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 毛秉智 | Beijing Institute of Radiation Medicine, Beijing 100850, China | |
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| Abstract:: |
| Objective To study the changes of haptoglobin expression in mouse serum and hematopoietic immune tissue, in order to search for the potential diagnostic biomarker and therapeutical target of acute radiation injury.Methods RT-PCR and Western blotting were used to detect the haptoglobin mRNA and protein, respectively.Results The expression of haptoglobin mRNA in detected tissues and protein in sera were increased in dose- and time-dependent manner.Conclusions γ-rays could enhance the expression level of haptoglobin in mouse serum and hematopoietic immune tissue, and these two proteins might be the potential diagnostic biomarker or therapeutical target of acute radiation injury. |
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