| PIAO Yong-feng,CHEN Da-wei,JIA Xiao-jing,et al.Effects of low dose half-body irradiation on immune function in patients with malignant tumor[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):33-35 |
| Effects of low dose half-body irradiation on immune function in patients with malignant tumor |
| Received:May 20, 2007 |
| DOI： |
| KeyWords:Low dose half-body irradiation Malignant tumor Immune function |
| FundProject:吉林省科技厅重点基金资助项目(20050413-5) |
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| Abstract:: |
| Objective To evaluate the effects on the immune function by low dose half-body irradiation. Methods Twenty patients, 13 non-Hodgkin's lymphoma and 7 small cell lung cancer, were randomly divided into two groups: HBR and RR. 10 patients of HBR were administrated with routine radiotherapy and low dose of half-body irradiation with 10 cGy once, twice every week. The routine radiotherapy was performed 6-8 h after low dose half-body irradiation and the total dose is 100 cGy. The other 10 patients of RR were given with routine radiotherapy alone. The changes in CD4, CD8, CD25 and CD56 of the peripheral blood lymphocyte between HBR and RR were measured by flow cytometry pro-, midst- and post-radiotherapy.Results The CD4+ CD8+ for RR patients was decreased after irradiation (P<0.05). For HBR patients, CD4+, as well as the expression of CD25+ and CD56+ molecule were significantly increased (P<0.05,P<0.05).CD8+ was decreased pro-, post-radiotherapy (P<0.05), but CD4+ CD8+ was increased midst-(P<0.05) and post-radiotherapy (P<0.01). Conclusions Low dose half-irradiation could enhance the immune function. |
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