| DENG Chong,ZHANG Quan,TIAN Ye.Alteration of Tau protein in rat oligodendrocytes after early radiation-induced brain injuries[J].Chinese Journal of Radiological Medicine and Protection,2008,28(1):28-31 |
| Alteration of Tau protein in rat oligodendrocytes after early radiation-induced brain injuries |
| Received:December 22, 2006 |
| DOI： |
| KeyWords:Radiation-induced brain injury Early stage Oligodendrocyte Tau protein Immunohistochemistry |
| FundProject:国家自然科学基金资助项目(30170287);江苏省卫生厅重大科研课题(K2004067);苏州大学医学发展基金资助项目(EE123504) |
| Author Name | Affiliation | E-mail | | DENG Chong | Department of Radiotherapy and Oncology, Second Affiliate Hospital, Soochow University, Suzhou 215004, China | | | ZHANG Quan | Department of Radiotherapy and Oncology, Second Affiliate Hospital, Soochow University, Suzhou 215004, China | | | TIAN Ye | Department of Radiotherapy and Oncology, Second Affiliate Hospital, Soochow University, Suzhou 215004, China | dryetian@hotmail.com |
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| Abstract:: |
| Objective To observe the expression of Tau protein in oligodendrocytes within subcortical white matter at different doses and time-points after whole-brain irradiation.Methods A model of brain radiation-induced injury was established in rat after whole-brain irradiation with single dose of 4 MeV electron beam. The expression of Tau-1 and Tau-5 in oligodendrocytes within subcortical white matter was analyzed by immunohistochemistry at different time-points (24 hours, 1 week and 1 month) and different doses (2, 10 and 30 Gy).Results The expression of Tau-1 in oligodendrocytes reached the peak level in 24 hours, which was 1.5-2 times as high as the normal group. It began to decrease after 1 week and returned to the normal level in 1 month. The expression levels of Tau-5 showed no difference at different time points (P>0.05).Conclusions Tau protein in oligodendrocytes undergo rapid and temporal dephosphorylation after early radiation-induced brain injury in a dose-dependent manner. It is suggested that Tau protein might play an important role in the early stage of brain radiation injury. |
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