| LIU Yong,WANG Deng-gao,ZHANG Guang-bin,et al.Effects of microwave exposure on motor learning and GluR2 phosphorylation in rabbit cerebellum[J].Chinese Journal of Radiological Medicine and Protection,2007,27(6):599-601 |
| Effects of microwave exposure on motor learning and GluR2 phosphorylation in rabbit cerebellum |
| Received:November 16, 2006 |
| DOI： |
| KeyWords:Microwave exposure Cerebellum Motor learning GluR2 Phosphorylation |
| FundProject:国家自然科学基金资助项目(30170237) |
| Author Name | Affiliation | E-mail | | LIU Yong | Department of Military Occupational Hygiene, The Third Military Medical University, Chongqing 400038, China | xushui290@yahoo.com.cn | | WANG Deng-gao | Department of Military Occupational Hygiene, The Third Military Medical University, Chongqing 400038, China | | | ZHANG Guang-bin | Department of Military Occupational Hygiene, The Third Military Medical University, Chongqing 400038, China | | | 周文 | Department of Military Occupational Hygiene, The Third Military Medical University, Chongqing 400038, China | | | 杨学森 | Department of Military Occupational Hygiene, The Third Military Medical University, Chongqing 400038, China | |
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| Abstract:: |
| Objective To investigate the effects of microwave exposure on motor learning and Glutamate receptor 2(GluR2) phosphorylation in rat cerebellum. Methods The rabbits were trained for seven days to form eye_blink conditioning,and then divided randomly into control and microwave exposure group (at hours 0,3,24 and 72 subgroups after exposure,respectively). The rabbits were accepted 90 mW/cm2 microwave exposure for 30 minutes, and the rectal temperature were detected immediately after exposure and specific absorption rate (SAR) value were calculated. Eye-blink conditioning were detected immediately after exposure, and cerebellar GluR2 protein and GluR2 phosphorylation were detected with Western blotting. Results Rectal temperature of rabbits were increased by 3.02℃ after exposure, and SAR value was 8.74 W/kg. The eye_blink conditioning decreased significantly after exposure, and cerebellar GluR2 protein expression had no significant alteration but phosphorylation reduced significantly after exposure. Conclusions 90 mW/cm2microwave exposure has injurious effects on cerebellar GluR2 phosphorylation and motor learning. |
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