| SHEN Guang-jian,TANG Wen-Yuan,XU Min-hui.AQP4 expression and its relationship with brain edema after gamma kife radiosurgery in rats[J].Chinese Journal of Radiological Medicine and Protection,2007,27(6):552-554 |
| AQP4 expression and its relationship with brain edema after gamma kife radiosurgery in rats |
| Received:November 12, 2006 |
| DOI： |
| KeyWords:Gamma knife radiosurgery AQP4 Brain edema |
| FundProject: |
| Author Name | Affiliation | E-mail | | SHEN Guang-jian | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | TANG Wen-Yuan | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | XU Min-hui | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | 邹咏文 | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | 耿明英 | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | 李飞鹏 | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | | | 孙善全 | Department of Neurosurgical, Daping hospital, The Third Military Medical College, Chongqin 400042, China | sunsq2151@soho.com |
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| Abstract:: |
| Objective To explore AQP4 expression and its relationship with brain edema after gamma knife radiosurgery (GKRS) in rats. Methods Wistar rats were divided into two groups-the control group and experimental group. The experimental group model was established by radiating rat left rotral caudate nucleus with GKRS (100 Gy, 4 mm), and was examinded at interval times of 1 d, 3 d, 7 d, 15 d, 30 d and 45 d. Brain water content (BWC) was determined by wet-dry weighing method. AQP4 expression on mRNA and protein were measured by immunohistochemistry (ICH) and in situ hybridization (ISH). Results In control group,AQP4 protein and its mRNA were expressed in subpial astrocytes, choroid plexus, ependyma and perivascular astrocytes. After GKRS,AQP4 protein and its mRNA in these sites were enhanced,and became most remarkable at 30 d. The positive corrlationship was showed between AQP4 and its mRNA,and AQP4 and BWC. Conclusions AQP4 protein and its mRNA can be induced in some brain zone after irradiating rat left rotral caudate nucleus with GKRS. The increased expression of AQP4 and its mRNA may play a role in the ocurrence or development of brain edema after GKRS. |
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