| ZHOU Zhi-guo,ZHANG Ping,et al.The long effect of 7-day continuous accelerated irradiation in patients with esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2007,27(6):549-551 |
| The long effect of 7-day continuous accelerated irradiation in patients with esophageal carcinoma |
| Received:November 27, 2006 |
| DOI： |
| KeyWords:Esophageal cancer Radiotherapy Accelerated fractionation Survival rate Overall treatment time |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHOU Zhi-guo | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | | | ZHANG Ping | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | | | 高献书 | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | gaoxs@heinfo.net | | 乔学英 | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | | | 王薇 | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | | | 万钧 | Department of Radiation Oncology, 4th Hospital of Hedical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective The curative effect of 7-day continuous accelerated irradiation schedule (CAIR) was compared with late course accelerated hyper-fractionation radiotherapy schedule (LCAF) for esophageal carcinoma in a randomized trial. Methods Fifty-seven patients with squamous cell carcinoma of esophagus were randomly divided into two groups, 29 to the CAIR group and 28 to the LCAF group. In CAIR group dose per fraction of 2.0 Gy was given once per day at 24 h intervals and the overall treatment time was 4.2 weeks (30 days). The patients in the LCAF group received conventional fractionation radiotherapy, 2 Gy/fraction, to a dose of 30 Gy in 15 fractions during 3 weeks, followed by accelerated fractionation radiotherapy, 2 fractions per day at 1.5 Gy/fraction (with a minimal interval of 6 h between fractions), and the overall treatment time was 5 weeks. The total dose was 60 Gy in both groups. Results The 1,2 and 3-year overall survival rate were 62.07%, 37.93% and 25.60% in CAIR group and 64.29%, 35.71% and 25.00% in LCAF group. The 3-year local control rate was 52.94% and 40.84% in CAIR and LCAF groups, respectively. The 3-year cause-specific survival rate was 28.72% in CAIR and 25.00% in LCAF group. There was no significant difference of late effect in two groups.Conclusions The 3-year survival rate and local control rate were similar in two groups. The local relapse and metastasis were the main reason of failure to radiotherapy to esophageal carcinoma. |
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