| ZHENG Hui,ZHEN Rong,LIAO Jing-hui.Changes in nitric oxide content, anti_superoxide anion radicals and total ability of anti_oxidize in rat after distinct stage of irradiation[J].Chinese Journal of Radiological Medicine and Protection,2007,27(6):546-548 |
| Changes in nitric oxide content, anti_superoxide anion radicals and total ability of anti_oxidize in rat after distinct stage of irradiation |
| Received:July 16, 2007 |
| DOI： |
| KeyWords:Irradiation damage Nitric oxide Anti-superoxide anion radicals Total ability of anti-oxidization |
| FundProject: |
| Author Name | Affiliation | | ZHENG Hui | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | ZHEN Rong | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | LIAO Jing-hui | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 涂序珉 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 张志兴 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China |
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| Abstract:: |
| Objective To investigate the changes in nitric oxide (NO) content, anti-superoxide anion radicals and total ability of anti-oxidize in rat after iradiation damage.Methods The five groups rats were irradiated with 60Co gamma rays (0.4,0.8,1.6,3.2 and 6.4 Gy). The NO content, anti-superoxide anion radicals and total ability of anti-oxidization outside-inside cell were measured after distinct stages of irradiation.Results 1 At 1 day after irradiation,the content of NO was significantly increased outside-inside cell and the range of changes was related to the increase of irradiation dosage. At 21 days after irradiation, the content of NO was lower than that at 1 day after irradiation, but the levels of NO at dose over 0.8 Gy were still higher than that in normal group. 2 Irradiation could hurt the defensive ability of the free radicals, and the degree of harm had relation with the irradiated dose. The defensive ability of the free radicals could recover after low irradiated dose, but it recovered slowly over 1.6 Gy dose and never recovered over 3.2 Gy dose due to animal death.Conclusions Irradiation could induce the injury of anti-superoxide anion radicals and total ability of anti-oxidize, and increase the content of nitric oxide. This degree of changes was related to the irradiated dosage. In convalescence stage after irradiation, these abnormal changes could be significantly improved. |
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