| FENG Li,WANG Lin-chao,HOU Dian-jun.Effects of low dose radiation on tumor-bearing mice[J].Chinese Journal of Radiological Medicine and Protection,2007,27(6):543-545 |
| Effects of low dose radiation on tumor-bearing mice |
| Received:August 16, 2006 |
| DOI： |
| KeyWords:Low dose Local irradiation Immune funtion Inhibitory effect |
| FundProject:山东省科技厅攻关项目(2004GGB02092) |
| Author Name | Affiliation | E-mail | | FENG Li | Institute of Radiation medicine, Shandong Academy of Medcine Sciences, Jinan 250062, China | | | WANG Lin-chao | 济钢防疫站 | | | HOU Dian-jun | Institute of Radiation medicine, Shandong Academy of Medcine Sciences, Jinan 250062, China | | | 程玉峰 | 山东大学齐鲁医院 | | | 黄山英 | Institute of Radiation medicine, Shandong Academy of Medcine Sciences, Jinan 250062, China | | | 邓大平 | Institute of Radiation medicine, Shandong Academy of Medcine Sciences, Jinan 250062, China | qqddfl1998@163.com |
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| Abstract:: |
| Objective To explore the effects of low-dose radiation on tumor-bearing mice and radiotherapy induced by low-dose radiation.Methods Male Wistar mice were implanted with Walker-256 sarcoma cells in the right armpit.On day 4,the mice were given 75 mGy whole_body X-ray radiation. From the fifth day, tumor volume was measured, allowing for the creation of a graph depicting tumor growth. Lymphocytes activity in mice after whole-body X-ray radiation with LDR was determinned by FCM. Cytokines level were also determined by ELISA.Results Compared with the radiotherapy group, tumor growth was significantly slower in the mice pre-exposed to low-dose radiation (P<0.05),after 15 days,the average tumor weight in the mice pre-exposed to low-dose radiation was also significantly lower(P<0.05). Lymphocytes activity and the expression of the CK in mice after whole-body γ-ray radiation with LDR increased significantly.Conclusions Low-dose radiation can markedly improve the immune function of the lymphocyte, inhibit the tumor growth, increase the resistant of the high-dose radiotherapy and enhance the effect of radiotherapy. |
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