| XIA De-hong,XI Lei,SHEN Wei-sheng.Anti-radiation effect of Erdosteine on injuries of lungs in patients with lung radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2007,27(5):488-490 |
| Anti-radiation effect of Erdosteine on injuries of lungs in patients with lung radiotherapy |
| Received:September 20, 2006 |
| DOI： |
| KeyWords:Radiotherapy Erdosteine Lung injuries Tumor necrosis factor |
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| Abstract:: |
| Objective To observe the anti-radiation effect of Erdosteine on radioprotection of lung and expression of plasma tumor necrosis factor α(TNF-α) in patients with lung radiotherapy. Methods Sixty lung irradiated patients were randomized into control group(30 patients)and therapy group(30 patients). Therapy group was administered with Erdosteine 0.6 g,po,b.i.d,for 3 months. Plasma TNF-α was examined by ELISA before and after radiotherapy.Clinical symptoms,lung function,and high-resolution computed tomography of thorax were evaluated at day 15 after the beginning of radiotherapy. Results At the end of radiotherapy,the level of TNF-α in control group was much higher than that in therapy group(5.06±1.03 ng/ml vs 2.38±0.78 ng/ml,P<0.001).At months 5 and 10 after radiotherapy,patients in the therapy group whose CO diffusion capacity of lung(DLCO) declined were less than those in the control group(P<0.05).Incidence of radiatior pneumonia and lung fibrosis was statistically different between the two groups. Conclusions Erdosteine can inhibit overexpression of plasma TNF-α after radiotherapy,and may reduce the severity of dysfunction lung injury. Erdosteine can prevent and treat the radioactive lung injuries. |
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