| ZHONG Ya-hua,ZHOU Yun-feng,XIE Cong-hua.Effecacy of radiotherapy on carcinomatous meningitis in 42 patients[J].Chinese Journal of Radiological Medicine and Protection,2007,27(5):477-479 |
| Effecacy of radiotherapy on carcinomatous meningitis in 42 patients |
| Received:January 04, 2007 |
| DOI： |
| KeyWords:Radiotherapy Carcinoma Carcinomatous meningitis |
| FundProject: |
| Author Name | Affiliation | | ZHONG Ya-hua | Department of Chemo-Radiation Oncology, Zhongnan Hospital, Wuhan University, Hubei 430071, China | | ZHOU Yun-feng | Department of Chemo-Radiation Oncology, Zhongnan Hospital, Wuhan University, Hubei 430071, China | | XIE Cong-hua | Department of Chemo-Radiation Oncology, Zhongnan Hospital, Wuhan University, Hubei 430071, China | | 王骁踊 | Department of Chemo-Radiation Oncology, Zhongnan Hospital, Wuhan University, Hubei 430071, China |
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| Abstract:: |
| Objective To investigate the effecacy of radiotherapy on carcinomatous meningitis and observe the factors which influenced prognosis. Methods Forty-two patients with carcinomatous meningitis were involved in the retrospective analysis. All patients received whole brain radiotherapy. Among 9 patients with spine involved, 4 patients received whole spine radiation and 5 patients received focal spine radiation. The prognosis factors were analyzed with Cox regression analysis. Results Clinical improvement was documented in 19 of 42 patients (45.2%). Thirty-five patients had a follow-up CT or MRI. A size reduction of lesions was seen in 14 patients (40%). The medium survival time was 3.7 months (ranging from 0.8 months to 32.4 months). Age(≤60), KPS(＞60) and breast cancer were independent factors significantly associated with longer survival term in the univariate analysis. In a multivariate analysis, only KPS＞60 was confirmed as a positive prognostic factor. Conclusions Radiotherapy is an effective way on carcinomatous meningitis. KPS is an independent prognosis factor. |
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