| YANG Ming-hui,ZANG Qian,DOU Yong-qi,et al.Modulation by Blood-cooling and Blood Flow-promoting Herbs to the expression of TNF-α and bFGF in radiation induced lung damage of rats[J].Chinese Journal of Radiological Medicine and Protection,2007,27(5):438-440 |
| Modulation by Blood-cooling and Blood Flow-promoting Herbs to the expression of TNF-α and bFGF in radiation induced lung damage of rats |
| Received:September 29, 2006 |
| DOI： |
| KeyWords:Radiation-induced injury of lung Tumor necrosis factor α Basic fibroblast growth factor Blood-cooling and Blood Flow-promoting Herbs |
| FundProject:国家自然科学基金资助项目(30371826) |
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| Abstract:: |
| Objective To observe the modulation by Blood-cooling and Blood Flow-promoting Herbs to expressions of tumor necrosis factor α (TNF-α) and basic fibroblast growth factors (bFGF) in radiation-induced lung injury of rats at different radiation times, and explore the mechanism of prevention and curative effect of the herbs on radsation lurg injury. Methods 160 wistar rats were randomly allocated into irradiation group, treatment group, herb- fracture group and control group. The first two groups were irradiated to right hemithorax with a dose of 30 Gy/10 fraction/5 weeks. Animals were sacrificed at weeks 3,5,8,12 and 26 post irradiation the level of immunoreactivity of cytokine TNF-α and bFGF was evaluated. Results The acute radiation-induced pneumonia ocurred at weeks 3 and was most serious at weeks 5 and pulmonary fibrosis was remarkable at the late phase in irradiation group. The pneumonia and fibrosis of treatment group were lighter than that of irradiation group. Expressions of TNF-α and bFGF reached their peaks at weeks 5 and 26 of respectively. The expressions in treatment group was significantly lower than that the irradiation group(P＜0.01). Conclusions Blood-cooling and Blood Flow_promoting Herbs can prevent and treat the radiation-reduced lung injury by restraining the expression of TNF-α and bFGF. |
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