| BING Tao,HU Xiang-kai,DANG Bing-rong,et al.Effects of heavy ions and X-ray irradiations on mice bone marrow cell cycle distribution[J].Chinese Journal of Radiological Medicine and Protection,2007,27(5):425-426 |
| Effects of heavy ions and X-ray irradiations on mice bone marrow cell cycle distribution |
| Received:September 20, 2006 |
| DOI： |
| KeyWords:Heavy ion irradiation X-ray Cell cycle Bone marrow cell |
| FundProject:“西部之光”资助项目(XB040602);国家自然科学基金重点资助项目(10335050);甘肃省青年科学基金资助项目(3ES041-A25-025) |
| Author Name | Affiliation | E-mail | | BING Tao | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | | | HU Xiang-kai | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | | | DANG Bing-rong | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | dangbr@impcas.ac.cn | | 谢漪 | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | | | 荆西刚 | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | | | 李文建 | Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China | |
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| Abstract:: |
| Objective To investigate the effects of whole body irradiation with heavy ions and X-ray at different doses on mice bone marrow cell cycle distribution, and to provide the basic data for biological-object-oriented hadrontherapy(OOBH). Methods The BALB/c mice were irradiated with heavy ions and X-ray, and the bone marrow cells were harvested after 24 hours, and then the cell cycle distribution were analyzed by flow cytometry. Results At 24 h after irradiation, bone marrow cell cycle distribution of the X-ray groups were not different from the control. While in the heavy ions irradiation groups, G1/G0 phase and G2/M phase were markedly arrested compared with the control group as well as X-ray irradiation group at the same dose. Conclusions The heavy ions irradiation was more dangerous on the mice bone marrow cells than the X-ray irradiation at the same doses. They induced different relative biological effects. |
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