| LI Rong,LENG Yan-bing,AI Guo-ping,et al.Reproductive toxicity in rats after chronic oral exposure to low dose of depleted uranium[J].Chinese Journal of Radiological Medicine and Protection,2007,27(5):417-420 |
| Reproductive toxicity in rats after chronic oral exposure to low dose of depleted uranium |
| Received:October 09, 2006 |
| DOI： |
| KeyWords:Depleted uranium Low dose Reproductive toxicity Intake |
| FundProject:国家自然科学基金资助项目(30670625);全军“十一五”科研基金专项项目(06Z031);中国博士后基金(2006039068) |
| Author Name | Affiliation | E-mail | | LI Rong | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | | LENG Yan-bing | 成都医学院公共卫生学教研室 | | | AI Guo-ping | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | | 徐辉 | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | | 粟永萍 | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | Suyping@yahoo.com | | 程天民 | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | |
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| Abstract:: |
| Objective To study the reproductive toxicity in rats induced by low dose of depleted uranium (DU). Methods Male and female rats(F0 generation) were exposed to DU in food at doses of 0, 0.4, 4and 40 mg·kg-1·d-1 for 160 days,respectively. Then the activities of enzymes in testis and sexual hormone contents in serum were detected. Mature male rats were mated with female rats exposed to the same doses for 14 days. Pregnant rate and normal labor rate in F0 rats were detected, as well as the survival rate and weight of F1 rats within 21 d after birth. Results No adverse effects of DU on fertility were evident at any dose in F0 rats. Compared with control group, the rate of pregnancy, normal labor, survival of offspring birth and offspring nurture in F1 generation of high_dose group reduced to 40.0%, 33.3%, 33.3%, and 33.3%, respectively. The sexual hormone contents in F0 generation exposed increased, but those in F1 rats decreased significantly. The activities of lactate dehydrogenase-X (LDH-X) decreased in F0 rats exposed to high-dose of DU, and those of sorbitol dehydrogenase (SDH), LDH and Na+-K+-ATPase decreased in F1 rats exposed to DU. Conclusions Reproduction function, growth and development of F0 rats are not obviously affected after chronic oral exposure to DU, while the toxicity effects in F1 generation was observed at any dose. |
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