| FANG Tong,GAO Hong,FENG Guo-sheng,et al.Therapeutic effects of the different gross tumor volume three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with hepatocellular carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2007,27(4):343-345 |
| Therapeutic effects of the different gross tumor volume three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with hepatocellular carcinoma |
| Received:December 18, 2006 |
| DOI： |
| KeyWords:Hepatocellular carcinoma Portal thrombus 3-dimensional conformal radiotherapy Transcatheter arterial chemoembolization |
| FundProject: |
| Author Name | Affiliation | | FANG Tong | Beijing Shijitan Hospital. Departement of Radiation Oncology, Beijing 100038, China | | GAO Hong | Beijing Shijitan Hospital. Departement of Radiation Oncology, Beijing 100038, China | | FENG Guo-sheng | Beijing Shijitan Hospital. Departement of Radiation Oncology, Beijing 100038, China | | 陈力 | Beijing Shijitan Hospital. Departement of Radiation Oncology, Beijing 100038, China | | 孙保锦 | Beijing Shijitan Hospital. Departement of Radiation Oncology, Beijing 100038, China | | 刘丽 | 内蒙古医学院附属人民医院 |
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| Abstract:: |
| Objective To analyze the clinical efficacy of 3-dimensional conformal radiotherapy(3DCRT) combined with intervention of the different gross tumor volume (GTV) and transcatheter arterial chemoembolization (TACE) for portal vein tumor thrombus(PVTT) in hepatocellular carcinoma.Methods 30 patients with unresectable hepatocellular carcinoma complicated with tumor thrombus in the portal vein were enrolled into the study from March 2002 to January 2005. All patients were randomly divided into two groups: group A including 15 cases with the gross tumor volume included intrahepatic tumor and portal vein tumor thrombus, Group B including 15 cases with the gross tumor volume defined as only PVTT. Intrahepatic tumor was not involved in the GTV. RT was started 1-2 factions following TACE. Results The effective rates in group A and group B were 33.3% and 53.3%, respectively (P＞0.05). Survival rates at 1st and 2nd years were 26.7% , 6.7% in group A and 40.0%, 13.3% in group B, respectively (P＞0.05). Radiation toxicity was significantly more frequent in group A than that of group B(P＜0.05).Conclusions 3DCRT combined with TACE is an effective method for treatment of portal vein tumor thrombus in hepatocellular carcinoma,especially those patients with intrahepatic tumor of multiple or massive and poor liver function. The combined therapy may improve the quality of patient's life and lower the incidence of toxicity. |
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