| SHEN Ye-shou,ZHENG Yuan,LI Geng,et al.Study on radioprotective activity in mice of Polysaccharides from Armillariella tabescen[J].Chinese Journal of Radiological Medicine and Protection,2007,27(4):340-342 |
| Study on radioprotective activity in mice of Polysaccharides from Armillariella tabescen |
| Received:July 31, 2006 |
| DOI： |
| KeyWords:Armillariella tabescens Polysaccharides Radiation damage White blood cell Immune organs |
| FundProject: |
| Author Name | Affiliation | E-mail | | SHEN Ye-shou | Laboratory of Glycoconjugates and Glycotechnology, School of Life Science, Anhui University, Hefei 230039, China | shysh@ahu.edu.cn | | ZHENG Yuan | Laboratory of Glycoconjugates and Glycotechnology, School of Life Science, Anhui University, Hefei 230039, China | | | LI Geng | Laboratory of Glycoconjugates and Glycotechnology, School of Life Science, Anhui University, Hefei 230039, China | | | 肖金鑫 | Laboratory of Glycoconjugates and Glycotechnology, School of Life Science, Anhui University, Hefei 230039, China | |
|
| Hits: 3910 |
| Download times: 2073 |
| Abstract:: |
| Objective To explore the protective effect of Armillariella tabescen Sing (ATS) on radiation injury in mice.Methods The mice were divided into six groups randomly, including normal group (0.9% physiological salt solution), radiation model group, positive group (Shenqipian, SQP) and experiment groups of different doses of ATS(80, 160, 320 mg/kg).The model was made in mice by γ-ray. After irradiation, 30 day survival rate were observed. WBC counts, micronucleus(MN) test in mouse bone marrow polychromatic erythrocytes (PCE) and sperms abnormality were detected. The content of deoxyribonucleic acid (DNA) in bone marrow, index of thymus and spleen, superoxide dismulases (SOD) activities and malondialdehyde (MDA) levels in serum and liver were measured. Results ATS could obviously increase the 30 day survival rate,content of DNA in bone marrow (P<0.05), number of the colony forming unit of spleen (CFU-S) (P<0.05) and SOD activities (P<0.05). It markedly resist the decrease of the number of white blood cell (WBC) (P<0.05), weights of thymus and spleen. It also could decrease MDA levels (P<0.05), rate of MN (P<0.05) and sperms abnormality frequency (SF) significantly (P<0.05).Conclusions ATS is effective in protecting the γ-radiation injury in mice. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
