| LI Jian-feng,BU Liang,YANG Fan,et al.Influence of 125I seeds para-tracheal implantation on serum level of inflammatory cytokines IL-1β,IL-6 and TNF-α in rabbits[J].Chinese Journal of Radiological Medicine and Protection,2007,27(4):337-339 |
| Influence of 125I seeds para-tracheal implantation on serum level of inflammatory cytokines IL-1β,IL-6 and TNF-α in rabbits |
| Received:May 08, 2007 |
| DOI： |
| KeyWords:125I seeds Inflammatory cytokine Brachytherapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | LI Jian-feng | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | BU Liang | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | YANG Fan | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | 周足力 | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | 李运 | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | 赵辉 | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | | | 王俊 | Department of General Thoracic Surgery, People's Hospital, Peking University, Beijing 100034,China | jwangmd@yahoo.com |
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| Abstract:: |
| Objective To evaluate the influence of 125I seeds para-tracheal implant on serum level of inflammatory cytokines in rabbits.Methods 30 rabbits were randomized to 5 groups, 4 study groups and control group. The activities of seeds in study groups ranged from 11.1 MBq (0.3 mCi) to 33.3 MBq (0.9 mCi), and D90 were 21.1 to 139.0 Gy. The false seeds were used in control group. Four seeds with equal activity were implanted between trachea and esophagus in each rabbit under general anesthesia. The seeds were arranged according to the Paris principle. Serum samples were collected prior to, 30, 60 and 90 days after implantation. IL-1β,IL-6 and TNF-α levels were measured by ELISA. Results All rabbits were healthy and had weight gaining during study period except 5 died. Serum levels of IL-1β,IL-6 and TNF-α at the end of the first, second and third month were all slightly higher than those of pretreatment. However,there was no statistical significance among them except for group 2.Conclusions Interstitial brachytherapy with 125I seeds might not significantly produce systematic inflammatory reaction on rabbits. |
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