| ZHANG Li-yuan,YANG Shun,ZHANG Ming-zhi,et al.Experimental study of low dose radiation stimulate the haematogenesis reconstitution of the recipient after bone marrow transplantation in mice[J].Chinese Journal of Radiological Medicine and Protection,2007,27(4):331-333 |
| Experimental study of low dose radiation stimulate the haematogenesis reconstitution of the recipient after bone marrow transplantation in mice |
| Received:June 07, 2006 |
| DOI： |
| KeyWords:Low dose radiation Hormesis Mice Bone marrow transplantation |
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| Abstract:: |
| Objective To investigate if low dose radiation can stimulate the haematogenesis reconstitution of the recipient after bone marrow transplantation in mice.Methods Bone marrow cells were irradiated in vitro by different low dose radiation and then cultured in vitro. 3H-TdR incorporation was used to measure the reproductive activity of cells, and then the radiation dose with the best stimulating effect was determined. The donator myeloid cells were exposed to low dose radiation before the recipient mice received bone marrow transplantation; then the irradiated myeloid cells were infused to the recipient; and lastly, the counts of peripheral blood cells (PBC) and bone marrow mononuclear cells (BMMNC) were manitored in order to observe the effect of low dose radiation on haematogenesis reconstitution of the recipient animal after bone marrow transplantation.Results The reproductive activity of the bone marrow cells irradiated by 6 and 8 cGy could be improved significantly in vitro. When the recipient mice received bone marrow transplantation of the myeloid cells after low dose radiation, the counts of BMMNC and PBC were higher than those in the control group(P<0.05).Conclusions Low dose radiation can stimulate the haematogenesis reconstitution of the recipient after bone marrow transplantation. |
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