| TIAN Yuan,ZHANG Liang-an,DAI Guang-fu.The influence of nonuniform micro-distribution of alpha emitter on microdosimetry in cells[J].Chinese Journal of Radiological Medicine and Protection,2007,27(3):271-273 |
| The influence of nonuniform micro-distribution of alpha emitter on microdosimetry in cells |
| Received:May 22, 2006 |
| DOI： |
| KeyWords:Alpha radionuclide Nonuniform Micro-distribution Microdosimetry |
| FundProject:国家自然科学基金资助项目(10375091) |
| Author Name | Affiliation | E-mail | | TIAN Yuan | Department of Health Physics, The Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China | | | ZHANG Liang-an | Department of Health Physics, The Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China | lazhang@hotmail.com | | DAI Guang-fu | Department of Health Physics, The Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China | |
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| Abstract:: |
| Objective To study the influence of nonuniform micro-distribution of alpha emitter on cellular S values(in the radiommunotherapy). Methods Emission of alpha particles is randomly simulated by Monte Carlo method; the incident energy and exit energy are calculated with interpolation technique based on the relationship between range and energy of alpha particle and the analytical Continuous Slowing Down Approximation (CSDA) model. So energy deposited in the target area can be obtained. To take 213Po as an example, cellular S values with various cell dimensions and possible micro-distributions of radioactivity are calculated, such as linear increase, linear decrease, exponential increase and exponential decrease.Results S values from cell to cell of uniform distribution showed no difference with the Hamacher's results. S values of different micro-distributions are distinguishing with each other. It is indicated that different micro-distributions of radioactivity will result in significant change of average chord length of alpha particles traveling in the target area, as well as the change of average stopping power over the chord,which is primary reason for differences of S values.Conclusions The nonuniform micro-distributions show remarkable influence on cellular S values and hence should be taken consideration in cellular absorbed dose estimation, especially in microdosimetry. |
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